serine threonine Kinase 39 Proteins (STK39)

STK39 encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. Additionally we are shipping STK39 Antibodies (191) and STK39 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STK39 27347 Q9UEW8
STK39 54348 O88506
STK39 53416 Q9Z1W9
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Top STK39 Proteins at

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag   10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human S tag,His tag 100 μg Log in to see 15 to 18 Days
Insect Cells Human GST tag   5 μg Log in to see 11 to 12 Days

STK39 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine)

Top referenced STK39 Proteins

  1. Human STK39 Protein expressed in Wheat germ - ABIN1321704 : Mao, Ladd, Gad, Rastetter, Johnson, Marzbani, Childs, Lu, Dang, Broussard, Stanton, Hanash, Disis: Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer. in Journal of translational medicine 2014 (PubMed)

More Proteins for serine threonine Kinase 39 (STK39) Interaction Partners

Human serine threonine Kinase 39 (STK39) interaction partners

  1. STK39 acts as a tumor oncogene (show RAB1A Proteins) in non-small cell type lung cancer and can be a potential biomarker of carcinogenesis.

  2. In conclusion, these meta-analytical findings suggest that STK39 might not be a hypertension-susceptibility gene.

  3. Here, we report our replication data showing a significant association of the rs3754777 polymorphism, but not rs35929607, of STK39 with essential hypertension in a male Chinese Han population.

  4. Both SPAK and OSR1 (show OXSR1 Proteins) kinases entering cells through exosomes are preferentially expressed at the plasma membrane and that the kinases in exosomes are functional and maintain NKCC1 (show SLC12A2 Proteins) in a phosphorylated state.

  5. did not observe any significant difference in allele and genotype distribution between Parkinson's disease patients and controls for rs1955337 in STK39

  6. SPAK and OSR1 (show OXSR1 Proteins) are both stimulators of Kir2.1 (show KCNJ2 Proteins) activity.

  7. SPAK and OSR1 (show OXSR1 Proteins) are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb (show SLC34A2 Proteins)

  8. Single nucleotide polymorphisms STK39 and WNK1 (show WNK1 Proteins) were associated with hypertension and BP in our multicenter Belgian case-control study

  9. STK39 mRNA and protein express abnormally in primary hypertension patients with genetic variation, which is related to the blood pressure.

  10. SPAK protein has both the potential to up-regulate KCNQ1 (show KCNQ1 Proteins)/E1 protein abundance in the cell membrane, an effect possibly participating in the regulation of cell volume, excitability, epithelial transport and metabolism.

Mouse (Murine) serine threonine Kinase 39 (STK39) interaction partners

  1. SPAK plays a pathogenic role in IgA nephropathy through the activation of NF-kappaB (show NFKB1 Proteins)/MAPK (show MAPK1 Proteins) signaling pathway.

  2. Here, we show that specific expression of CA-SPAKwithin the early distal convoluted tubule (DCT1 (show SLC11A2 Proteins)) drives FHHt.

  3. Our data reveal that together SPAK and OSR1 (show OSR1 Proteins) play essential roles in the pathway along the distal convoluted tubules that responds to fluctuations in plasma potassium

  4. Genetic depletion of SPAK kinase reduces ischemic brain injury after occlusion of the left middle cerebral artery.

  5. the increased NCC (show SLC12A3 Proteins) expression and activation is present in CMA which is highly associated with the enhanced WNK4 (show WNK4 Proteins)-SPAK signal pathway using WNK4 (show WNK4 Proteins)-/- and SPAK-/- mice.

  6. We conclude that TRPV2 (show TRPV2 Proteins) is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK-activated NKCC1 (show SLC12A2 Proteins)

  7. SPAK has the potential to up-regulate ENaC (show SCNN1A Proteins)

  8. These observations establish that the CCT (show FLVCR2 Proteins) domain plays a crucial role in controlling SPAK activity and BP.

  9. The data of this study supported the gene-environment hypothesis and demonstrated the potential value of SPAK manipulation in future schizophrenia studies.

  10. The structure of partially active SPAK T243D is consistent with a multistage activation process in which phosphorylation induces a SPAK conformation that requires further remodeling to build the active structure.

STK39 Protein Profile

Protein Summary

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.

Gene names and symbols associated with STK39

  • serine/threonine kinase 39 (stk39)
  • serine/threonine kinase 39 (STK39)
  • serine/threonine kinase 39 L homeolog (stk39.L)
  • serine threonine kinase 39 (Stk39)
  • serine threonine kinase 39 (STK39)
  • serine/threonine kinase 39 (Stk39)
  • AW227544 protein
  • AW556857 protein
  • DCHT protein
  • MGC69537 protein
  • PASK protein
  • RF005 protein
  • Rnl5 protein
  • Spak protein

Protein level used designations for STK39

serine threonine kinase 39 (STE20/SPS1 homolog) , serine threonine kinase 39 (STE20/SPS1 homolog, yeast) , serine threonine kinase 39 , serine/threonine kinase 39 , STE20/SPS1 homolog , STE20/SPS1-related proline-alanine-rich protein kinase , Ste20-like protein kinase , proline-alanine-rich STE20-related kinase , serine/threonine-protein kinase 39 , small intestine SPAK-like kinase , ste-20-related kinase , PS/TK , PSTK1 , Ste-20 related kinase , pancreatic serine/threonine-protein kinase , kidney-specific SPAK , serine/threonine kinase 39, STE20/SPS1 homolog

407902 Xenopus (Silurana) tropicalis
459711 Pan troglodytes
704855 Macaca mulatta
100016925 Monodelphis domestica
100062610 Equus caballus
100598685 Nomascus leucogenys
446749 Xenopus laevis
27347 Homo sapiens
522103 Bos taurus
54348 Rattus norvegicus
424173 Gallus gallus
478779 Canis lupus familiaris
100517614 Sus scrofa
100714990 Cavia porcellus
53416 Mus musculus
100338897 Oryctolagus cuniculus
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