serine/threonine Kinase 31 Proteins (STK31)

Mouse (Murine) serine/threonine Kinase 31 (STK31) interaction partners

1. STK31 is expressed in embryonic gonocytes of both sexes and postnatal spermatocytes and round spermatids in males. Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development.

2. Stk31 is dispensable for both embryonic development and spermatogenesis in mice.

3. Our findings suggest mouse STK31 could be a potential nuage-associated protein in the cytoplasm of mid-to-late spermatocytes and play pivotal roles related to fertilization.

Human serine/threonine Kinase 31 (STK31) interaction partners

1. Relative STK31 expression level was significantly higher in patients with lymph node metastasis. STK31 expression levels in primary tumorous tissues of metastatic patients were significantly higher than in ANCTs and in lymph nodes samples, both at the RNA level and the protein level.

2. Study demonstrates that, except the testes, STK31 is not expressed in normal tissues but aberrantly expressed in pancreatic cancer (PC) tissues, indicating that STK31 is a cancer-testis (CT) gene in PC. STK31 is reactivated by demethylation and, significantly higher in relapsed patients, or patients with advanced pathologic stage or poorer prognosis, suggesting that STK31 might be of potential clinical value.

3. The human papillomavirus type 16 oncogene (show RAB1A Proteins) E7 may affect STK31 expression through a DNA methylation (show HELLS Proteins)-mediated mechanism.

4. the aberrant expression of STK31 contributes to tumorigenicity in somatic cancer cells

5. High STK31 expression is associated with colon cancer.