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STK36 encodes a member of the serine/threonine kinase family of enzymes.
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Dog (Canine) Polyclonal STK36 Primary Antibody for ELISA - ABIN4245725
Maloveryan, Finta, Osterlund, Kogerman: A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. in Journal of cell communication and signaling 2008
Data identified homozygous loss-of-function mutations in STK36 in one PCD (show Dnah5 Antibodies)-affected individual with situs solitus. Transmission electron microscopy analysis demonstrates that STK36 is required for cilia orientation in human respiratory epithelial cells, with a probable localization of STK36 between the RS and CP. STK36 screening can now be included for this rare and difficult to diagnose PCD (show Dnah5 Antibodies) subgroup.
Fu ubiquitination and cleavage is one of the key elements connecting the MID1 (show MID1 Antibodies)-PP2A (show PPP2R4 Antibodies) protein complex with GLI3 (show GLI3 Antibodies) activity control
Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
Hydrocephalus and suppurative otitis media indicate dysfunction of motile cilia in Stk36 null mice
This growth inhibition is partially rescued by expression of ectopic Gli1 (show GLI1 Antibodies), suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants.
serine/threonine kinase 36, fused homolog
, serine/threonine-protein kinase 36
, serine/threonine kinase 36
, serine/threonine-protein kinase 36-like
, fused homolog
, serine/threonine kinase 36 (fused homolog, Drosophila)