STK36 antibody

Catalog No. ABIN7118925

Product Details anti-STK36 Antibody

Target: STK36 (serine/threonine Kinase 36 (STK36))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK36 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: serine/threonine kinase 36, fused homolog(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for STK36

Target: STK36 (serine/threonine Kinase 36 (STK36))

Alternative Name: STK36 (STK36 Products)

Synonyms: FU antibody, fused-like antibody, 1700112N14Rik antibody, B930045J24 antibody, Fused antibody, mKIAA1278 antibody, fu antibody, si:dkey-180i4.3 antibody, zgc:152944 antibody, serine/threonine kinase 36 antibody, serine/threonine kinase 36 (fused homolog, Drosophila) antibody, STK36 antibody, Stk36 antibody, stk36 antibody

Background: Synonyms:KIAA1278 Background:Serine/threonine protein kinase which plays an important role in the sonic hedgehog(Shh) pathway by regulating the activity of GLI transcription factors(PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization(PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur(PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function(By similarity). Essential for construction of the central pair apparatus of motile cilia.

Molecular Weight: 144 kDa

Gene ID: 27148

UniProt: Q9NRP7