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May be a negative regulator of NF-kappa-B and p53- mediated gene transcription (By similarity). Additionally we are shipping serine/threonine Kinase 40 Antibodies (48) and many more products for this protein.
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STK40 binds the COP1 (show CARD16 Proteins) WD40 domain (show DCAF12L2 Proteins) using a VPD/E motif in its C-terminal tail.
Data indicate that STK40 was a direct target of microRNA miR (show MLXIP Proteins)-130a, and overexpressing miR (show MLXIP Proteins)-130a significantly upregulated NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins), SOX9 (show SOX9 Proteins), JNK (show MAPK8 Proteins) and p38MAPK (show MAPK14 Proteins) proteins.
identification as a negative regulator of NF-kappaB (show NFKB1 Proteins)- and p53 (show TP53 Proteins)-mediated gene transcription [SINK-homologous serine-threonine kinase]
comparison of microarray data between wild type and Stk40(-/-) E14.5 fetal liver cells reveals a potential role of aberrantly activated TNF-alpha (show TNF Proteins) signaling in Stk40 depletion induced dyserythropoiesis with a concomitant increase in cleaved caspase-3 (show CASP3 Proteins) and decrease in Gata1 (show GATA1 Proteins) proteins.
Loss of Stk40 is associated with impaired fetal skeletal muscle formation.
CCAAT/enhancer-binding protein (C/EBP) beta (show CEBPB Proteins) and C/EBPdelta (show CEBPD Proteins), two crucial pro-adipogenic transcription factors, are controlled at a translational level by serine/threonine kinase 40 (Stk40).
the results suggested that Stk40 may be critical in the development of preimplantation embryos.
Deletion of STK40 protein in mice causes respiratory failure and death at birth
report identification of a target gene of Oct4 (show POU5F1 Proteins), serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK (show MAPK1 Proteins) pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse embryonic stem cells.
May be a negative regulator of NF-kappa-B and p53- mediated gene transcription (By similarity).
serine/threonine kinase 40
, SINK-homologous serine/threonine kinase
, serine/threonine-protein kinase 40
, serine/threonine-protein kinase 40-like
, SINK-homologous serine/threonine-protein kinase
, Ser/Thr-like kinase
, sugen kinase 495
, ortholog of Ser/Thr-like protein kinase Lyk4
, serine/threonine-protein kinase lyk4
, Ser/Thr-like protein kinase lyk4