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Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Additionally we are shipping serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 Kits (21) and serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 Proteins (7) and many more products for this protein.
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our results showed that the lymphatic vessel density (LVD) was reduced in lung and stomach sections from kallistatin-overexpressing transgenic mice
KBP reduces expression of VEGF (show VEGFA Antibodies) and HIF-1alpha (show HIF1A Antibodies) nuclear translocation
Kallistatin functions as an endogenous lymphangiogenesis inhibitor and has an important part in the lymphatic metastasis of gastric cancer.Kallistatin was reduced in the cancer tissue and plasma of gastric cancer patients.
SNPs rs2093266 in the SERPINA4 is associated with the development of severe acute kidney injury (KDIGO stage 2-3) in critically ill patients with septic shock
oxidative stress induces down- or upregulation of kallistatin expression, depending on oxygen concentration, and kallistatin plays a novel role in mediating oxygen/exercise-induced HIF-1 (show HIF1A Antibodies)-eNOS (show NOS3 Antibodies)-NO pathway.
These findings reveal novel mechanisms of kallistatin in protection against senescence, aging, and cancer development by modulating miR (show MLXIP Antibodies)-34a and miR (show MLXIP Antibodies)-21 levels and inhibiting oxidative stress.
These findings suggested that kallistatin may be a promising agent that could be used to suppress cancer metastasis by inhibiting both angiogenesis and lymphangiogenesis.
generated a meta-marker model made up of SERPINA4 and PON1 (show PON1 Antibodies) that is useful as a differential diagnostic biomarker differentiating lung cancer from other lung diseases.
Our results indicate that during severe sepsis and septic shock, a decrease in plasma concentrations of kallistatin reflects increased severity and poorer outcome of disease.
data suggest that overexpression of kallistatin interferes with lymphopoiesis, ultimately impacting the level of circulating CD19 (show CD19 Antibodies)(+) B lymphocytes.
Kallistatin levels were correlated with some markers of systemic inflammation in the HIV population.
Increased kallistatin levels in type 1 diabetes and its relation with carotid intima media thickness may reflect vascular dysfunction and suggest a link between micro- and macro-angiopathy.
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
, kallikrein inhibitor
, peptidase inhibitor 4
, protease inhibitor 4 (kallistatin)
, serpin A4