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The protein encoded by SERPINF1 is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. Additionally we are shipping serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Kits (86) and serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Proteins (57) and many more products for this protein.
Showing 10 out of 181 products:
this study is the first to demonstrate that PEDF promotes HUCMSC proliferation and protects them from apoptosis by reducing p53 (show TP53 Antibodies) expression in the serum-free medium. This study provides crucial information for clinical-scale expansion of human umbilical cord mesenchymal stem cells .
Results show that the levels of miR (show MLXIP Antibodies)-9, PEDF and VEGF (show VEGFA Antibodies) are increased with diabetic nephropathy (DN) progression. miR (show MLXIP Antibodies)-9, VEGF (show VEGFA Antibodies) and PEDF are independent risk factors of DN.
No difference in the genotype frequency of rs7925131 or rs7942159 in PNPLA2 between the normal free fatty acids (FFA) group and the high FFA group in a Chinese Han population.
Results suggested that the pigment epithelium-derived factor (PEDF)/vascular endothelial growth factor (VEGF (show VEGF Antibodies)) ratio played a pivotal role in the spontaneous regression of infantile hemangioma (IH).
Non-cardiac ATGL (show PNPLA2 Antibodies)-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.
PEDF protects human glomerular mesangial cells from diabetes-derived oxidative stress via NOXO1 (show NOXO1 Antibodies)- iNOS (show NOS2 Antibodies) suppression.
In this study, folate receptor alpha (show FOLR1 Antibodies) (FRa (show FOSL1 Antibodies))-targeted nano-liposomes (FLP (show HPD Antibodies)) were designed to enhance the anti-tumor effect by targeting delivery of exogenous PEDF gene to cervical cancer cells..These results clearly showed that FLP (show HPD Antibodies) were desired carriers for PEDF gene and FLP (show HPD Antibodies)/PEDF might represent a potential novel strategy for gene therapy of cervical cancer.
Plasma PEDF and RBP4 (show POLR2D Antibodies) identified Insulin (show INS Antibodies) resistance in subjects with no prior diagnosis of diabetes.
results demonstrate a novel functional role of PEDF/LR axis in driving metastasis through ERK1/2-mediated EMT (show ITK Antibodies) in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and provided a promising prognostic marker in HCC (show FAM126A Antibodies).
PN-1 (show SERPINE2 Antibodies) and PEDF share structural and functional features, and expression patterns in the retina.
After cryotherapy of the sclera, pigment epithelium-derived factor levels increased 44.8% compared to untreated controlsand stayed at that level until day 14. It returned to baseline by day 21. (untreated).
the inhibitory effect of PEDF appears to be mediated via the processing of VEGF (show VEGFA Antibodies)-R2 by gamma-secretase
PEDF inhibits key steps in the angiogenic response of retinal capillary endothelial cells, including cell proliferation and vascular tubule formation. Gene expression of PEDF is negatively regulated by glucose (show ZNF236 Antibodies), insulin (show INS Antibodies) (via mTOR (show FRAP1 Antibodies)) and VEGF (show VEGFA Antibodies).
Results suggest that leptin (show LEP Antibodies) might elicit angiogenesis through vascular endothelial growth factor (show VEGF Antibodies) induction as well as pigment epithelium-derived factor suppression in pericytes.
PEDF promotes growth of pericytes through autocrine production of PDGFB.
PEDF and VEGFR-1 (show FLT1 Antibodies) have roles in the negative regulation of angiogenesis
data suggest that PEDF, via its potent antiangiogenic capabilities, may contribute to superior healing in wounds on the trunks of horses by protecting from excessive formation of vascular granulation tissue
PN-1 (show SCN9A Antibodies) and PEDF share structural and functional features, and expression patterns in the retina.
The findings indicate that PEDF functions as a tumor-suppressor gene in the occurrence of epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma.
Expression of GLUT1 (show SLC2A1 Antibodies) is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 (show SLC2A1 Antibodies) in the cell membrane that contributes to the impairment of the RPE (show RPE Antibodies) secretory function of PEDF.
Combination of neuroprotective factors Pedf plus docosahexaenoic acid (DHA) stimulates corneal nerve regeneration. Data suggest activation of Pedfr by Pedf (here, applied topically to treat corneal nerve injury) promotes regeneration of corneal nerve via up-regulation of release of DHA (here, also applied topically) and expression of specific nerve tissue/eye proteins. (Pedfr = pigment epithelium-derived factor receptor)
The renoprotective effects of PEDF are mediated, at least partially, by inhibition of the Wnt (show WNT2 Antibodies) pathway in kidneys.
PEDF deficiency has a significant impact on retinal endothelial cell adhesion and migration through altered production of extracellular matrix and junctional proteins in response to increased oxidative stress affecting their proangiogenic activity.
PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation.
These results indicate that PEDF counters Wnt (show WNT2 Antibodies) signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF null state results in OI type VI.
Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a (show WNT3A Antibodies)-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (show SOD2 Antibodies)) and catalase (show CAT Antibodies).
Study demonstrated the inhibitory effect of PEDF on insulin (show INS Antibodies)-dependent molecular mechanisms of glucose homeostasis, and suggests that PEDF could be a specific target in the management of metabolic disorders.
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.
, adipose triglyceride lipase
, calcium-independent phospholipase A2
, patatin-like phospholipase domain containing protein 2
, patatin-like phospholipase domain-containing protein 2
, pigment epithelium-derived factor
, transport-secretion protein 2.2
, triglyceride hydrolase
, cell proliferation-inducing gene 35 protein
, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
, serpin F1
, alpha-2 antiplasmin
, pigment epithelium derived factor
, serpin peptidase inhibitor, clade F, member 1
, serine (or cysteine) proteinase inhibitor, clade F), member 1
, serine (or cysteine) proteinase inhibitor, clade F, member 1
, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
, alpha-2 antiplasmin, pigment epithelium derived factor
, pigment epithelium-derived factor-like
, stromal cell derived factor 3
, stromal cell-derived factor 3
, serine (or cysteine) peptidase inhibitor, clade F, member 1