anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) Antibodies

The protein encoded by SERPINF1 is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. Additionally we are shipping serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Kits (86) and serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Proteins (60) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SERPINF1 5176 P36955
SERPINF1 20317 P97298
SERPINF1 287526  
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Top anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Antibodies at antibodies-online.com

Showing 10 out of 177 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-SERPINF1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Placenta Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SERPINF1 Antibody (N-term) (ABIN391482) in 293 cell line lysates (35 µg/lane). SERPINF1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SERPINF1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of extracts of human liver , using SERPINF1 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276810 staining HepG2? cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB Western blot With PEDF antibody. Figure A: Lane 1: 50 µg Jurkat cell lysate. Lane 2: 50 µg 3T3 cell Lysate. Lane 3: 50 µg Mouse muscle lysate. Land 4: 50 µg Rat kidney lysate. Figure B: Lane 1: 2 ng Human recombinant PEDF Lane 2: 10 ng Human recombinant PEDF 100 μg Log in to see 2 to 3 Days
$265.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extract of 22Rv1 cells, using SERPINF1 antibody. 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SERPINF1 antibody (Center) (ABIN391483) in K562 cell line lysates (35 µg/lane). SERPINF1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SERPINF1 Antibody (Center) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Human Serum. 100 μg Log in to see 13 to 16 Days
$332.00
Details
Cow Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Skin (formalin-fixed, paraffin-embedded) stained with SERPINF1 antibody ABIN337231 at 4-8 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-PEDF antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 8 ug/ml. This image was taken for the unconjugated form of this product. Other forms ... 50 μg Log in to see 11 to 14 Days
$727.83
Details

Top referenced anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Antibodies

  1. Human Monoclonal SERPINF1 Primary Antibody for ELISA, WB - ABIN532937 : Morales, Townsend, Malone, Ewersmann, Macy, Inder, Limbrick: Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity. in Molecular & cellular proteomics : MCP 2012 (PubMed)

  2. Human Monoclonal SERPINF1 Primary Antibody for WB - ABIN533476 : Dawson, Volpert, Gillis, Crawford, Xu, Benedict, Bouck: Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 Pubmed References

More Antibodies against serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 Interaction Partners

Human serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. Findings confirm that both M1- and M2-like macrophages are essential for retinal neovascularization and uncover a vital protective role of PEDF against retinal neovascularization by regulating macrophage recruitment and polarization.

  2. results suggest that PEDF act as a multipotent factor in the skin and the imbalance of PEDF and VEGF may be responsible for the transformation from normal skin to psoriasis.

  3. expression unaltered in preterm prelabor rupture of the membranes (pRPOM) or after exposure to risk factors of pPROM

  4. Data found novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta

  5. Study showed that plasma PEDF levels were significantly lower in CAD patients than in controls.

  6. The T-C haplotype frequency of rs1136287-rs1894286 in PEDF were significantly correlated to the increased susceptibility to age-related macular degeneration(AMD). The rs1136287 polymorphism in PEDF may be related to the occurrence risk of AMD. Additionally, a haplotype is also a non-ignorable risk factor.

  7. this study is the first to demonstrate that PEDF promotes HUCMSC proliferation and protects them from apoptosis by reducing p53 expression in the serum-free medium. This study provides crucial information for clinical-scale expansion of human umbilical cord mesenchymal stem cells .

  8. Results show that the levels of miR-9, PEDF and VEGF are increased with diabetic nephropathy (DN) progression. miR-9, VEGF and PEDF are independent risk factors of DN.

  9. Results suggested that the pigment epithelium-derived factor (PEDF)/vascular endothelial growth factor (VEGF) ratio played a pivotal role in the spontaneous regression of infantile hemangioma (IH).

  10. PEDF protects human glomerular mesangial cells from diabetes-derived oxidative stress via NOXO1- iNOS suppression.

  11. In this study, folate receptor alpha (FRa)-targeted nano-liposomes (FLP) were designed to enhance the anti-tumor effect by targeting delivery of exogenous PEDF gene to cervical cancer cells..These results clearly showed that FLP were desired carriers for PEDF gene and FLP/PEDF might represent a potential novel strategy for gene therapy of cervical cancer.

  12. Plasma PEDF and RBP4 identified Insulin resistance in subjects with no prior diagnosis of diabetes.

  13. results demonstrate a novel functional role of PEDF/LR axis in driving metastasis through ERK1/2-mediated EMT in hepatocellular carcinoma (HCC) and provided a promising prognostic marker in HCC.

  14. PN-1 and PEDF share structural and functional features, and expression patterns in the retina.

  15. by inhibiting the phosphorylation of VEGFR2, the P18 peptide ( functional fragment of pigment epithelial-derived factor (PEDF)modulates signalling transduction between VEGF/VEGFR2 and suppresses activation of the PI3K/Akt cascades, leading to an increase in mitochondrial-mediated apoptosis and anti-angiogenic activity.

  16. Using AFM to image where exogenous hPEDF bound in rabbit femur, findings demonstrate that PEDF binds heterogeneously in cortical rabbit femur. Exogenous PEDF binding was concentrated at areas between microstructures with highly aligned collagen fibrils. Binding was not observed on or within the collagen fibrils themselves.

  17. PEDF was acutely regulated by a glucose load and was correlated with BMI but not with diabetes.

  18. The findings indicate that PEDF functions as a tumor-suppressor gene in the occurrence of epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma.

  19. the T allele of rs8075977 in the 5'-flanking region of the PEDF gene may be protective for Coronary Artery Disease

  20. PEDF exacerbates cartilage degeneration in an age-dependent manner under inflammatory conditions.

Pig (Porcine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. After cryotherapy of the sclera, pigment epithelium-derived factor levels increased 44.8% compared to untreated controlsand stayed at that level until day 14. It returned to baseline by day 21. (untreated).

  2. the inhibitory effect of PEDF appears to be mediated via the processing of VEGF-R2 by gamma-secretase

Cow (Bovine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. PEDF inhibits key steps in the angiogenic response of retinal capillary endothelial cells, including cell proliferation and vascular tubule formation. Gene expression of PEDF is negatively regulated by glucose, insulin (via mTOR) and VEGF.

  2. Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.

  3. PEDF promotes growth of pericytes through autocrine production of PDGFB.

  4. PEDF and VEGFR-1 have roles in the negative regulation of angiogenesis

Horse (Equine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. data suggest that PEDF, via its potent antiangiogenic capabilities, may contribute to superior healing in wounds on the trunks of horses by protecting from excessive formation of vascular granulation tissue

Mouse (Murine) serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) interaction partners

  1. PN-1 and PEDF share structural and functional features, and expression patterns in the retina.

  2. The findings indicate that PEDF functions as a tumor-suppressor gene in the occurrence of epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma.

  3. Expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE secretory function of PEDF.

  4. Combination of neuroprotective factors Pedf plus docosahexaenoic acid (DHA) stimulates corneal nerve regeneration. Data suggest activation of Pedfr by Pedf (here, applied topically to treat corneal nerve injury) promotes regeneration of corneal nerve via up-regulation of release of DHA (here, also applied topically) and expression of specific nerve tissue/eye proteins. (Pedfr = pigment epithelium-derived factor receptor)

  5. The renoprotective effects of PEDF are mediated, at least partially, by inhibition of the Wnt pathway in kidneys.

  6. PEDF deficiency has a significant impact on retinal endothelial cell adhesion and migration through altered production of extracellular matrix and junctional proteins in response to increased oxidative stress affecting their proangiogenic activity.

  7. PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation.

  8. These results indicate that PEDF counters Wnt signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF null state results in OI type VI.

  9. Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2) and catalase.

  10. Study demonstrated the inhibitory effect of PEDF on insulin-dependent molecular mechanisms of glucose homeostasis, and suggests that PEDF could be a specific target in the management of metabolic disorders.

  11. Alpha-2-Antiplasmin mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction via induction of TGF-beta.

  12. PEDF inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids in diabetic retinopathy.

  13. Data suggest that pigment epithelium-derived factor (PEDF) and adipose triglyceride lipase (ATGL) may serve as therapeutic targets for managing vascular hyperpermeability in sepsis.

  14. describe alterations in the PEDF signaling pathway and subventricular zone stem cell self-renewal at a very young age, which could be involved in the premature senescence observed in the SAM-P8 model

  15. The combination of rAAV-PEDF with hyperthermia has synergistic therapeutic effects on established solid tumors, with no side effects.

  16. PEDF mediates reduced vasculogenesis.

  17. The results demonstrated that PEDF can protect 661W cells against light-induced cell death and suggest that the binding of PEDF to cell surface PEDF-R triggers a prosurvival signaling pathway.

  18. data suggest that the PEDF expression makes significant contribution to modulation of the inflammatory and angiogenic phenotype of the lung endothelium

  19. PEDF suppresses IL-1beta-mediated JNK activation to improve hepatocyte insulin signaling

  20. Data suggest that Pedf (pigment epithelium-derived factor) is secreted from 3T3-L1 adipocytes, after treatment of the cell line with HDL (high density lipoprotein).

serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.

Gene names and symbols associated with SERPINF1

  • serpin family F member 1 (SERPINF1) antibody
  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (serpinf1) antibody
  • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog (serpinf1.L) antibody
  • serpin family F member 1 (Serpinf1) antibody
  • serine (or cysteine) peptidase inhibitor, clade F, member 1 (Serpinf1) antibody
  • AI195227 antibody
  • Dmrs91 antibody
  • EPC-1 antibody
  • MGC82984 antibody
  • OI6 antibody
  • OI12 antibody
  • Pedf antibody
  • Pedfl antibody
  • Sdf3 antibody
  • SERPINF1 antibody
  • zgc:92072 antibody

Protein level used designations for SERPINF1

cell proliferation-inducing gene 35 protein , pigment epithelium-derived factor , serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 , serpin F1 , alpha-2 antiplasmin , pigment epithelium derived factor , serpin peptidase inhibitor, clade F, member 1 , serpin-F1 , serine (or cysteine) proteinase inhibitor, clade F), member 1 , serine (or cysteine) proteinase inhibitor, clade F, member 1 , serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 , alpha-2 antiplasmin, pigment epithelium derived factor , pigment epithelium-derived factor-like , SDF-3 , caspin , stromal cell derived factor 3 , stromal cell-derived factor 3 , serine (or cysteine) peptidase inhibitor, clade F, member 1

GENE ID SPECIES
5176 Homo sapiens
780402 Sus scrofa
281386 Bos taurus
394686 Xenopus (Silurana) tropicalis
417561 Gallus gallus
444412 Xenopus laevis
468137 Pan troglodytes
611276 Canis lupus familiaris
100072415 Equus caballus
100192425 Ovis aries
100216362 Cavia porcellus
100403187 Callithrix jacchus
100457889 Pongo abelii
100482247 Ailuropoda melanoleuca
100580793 Nomascus leucogenys
20317 Mus musculus
287526 Rattus norvegicus
447800 Danio rerio
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