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TBXAS1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping thromboxane A Synthase 1 (Platelet) Antibodies (76) and thromboxane A Synthase 1 (Platelet) Kits (16) and many more products for this protein.
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Sequencing revealed two novel biallelic variants of unknown significance within the thromboxane A synthase gene, TBXAS1 (c.266T > C; c.989T > C), bioinformatically predicted to disrupt the protein. TBXAS1 mutations result in Ghosal hematodiaphyseal dysplasia (OMIM 231095), the autosomal recessive syndrome associated with abnormal bone structure and BMF (show BMF Proteins).
TXAS1 rs2267679TT and rs41708TT genotypes are associated with carotid plaque vulnerability, platelet activation and TXA2 (show TBXA2R Proteins) levels in ischemic stroke patients.
the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 (show TBXA2R Proteins) synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples.
Single nucleotide polymorphisms of TBXAS1 are associated with susceptibility to gout in ethnic Han males population.
The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 (show CYP2C9 Proteins) gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1.
The carriage of Thromboxane A synthase 1 gene polymorphism AA was shown to affect the risk of clopidogrel resistance.
study suggests that the anti-tumor effect of glycyrrhizin in lung adenocarcinoma is, at least in part, TxAS-dependent.
12-HHT (show ACVRL1 Proteins) is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi
In this study we have showed, for the first time, a significant role of the minor allele rs6962291 of TBXAS1 in patients with NSAID acute cutaneous hypersensitivity.
The increased Km and decreased Vmax values observed with L357V suggest that this variant may generate less TXA2 (show TBXA2R Proteins) at the low levels of PGH2 expected in vivo, raising the possibility of attenuated signaling through the thromboxane pathway.
TXAS mRNA expression was increased within the vascular wall in mouse models of atherosclerosis with advanced lesions.
thromboxane synthase, prostacyclin synthase (show PTGIS Proteins) and thromboxane receptor (show TBXA2R Proteins) have roles in atherosclerotic lesions and correlate with plaque composition
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, Thromboxane-A synthase
, thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
, thromboxane A synthase 1 (platelet)
, thromboxane-A synthase-like
, TXA synthase
, cytochrome P450 5A1
, cytochrome P450, family 5, subfamily A, polypeptide 1
, platelet, cytochrome P450, subfamily V
, thromboxane A synthase 1, platelet
, ThromboxA ane synthase 1