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The current meta-analysis provided solid evidence suggesting that ACE gene I/D polymorphism was probably a genetic risk factor for HCM.
Lower sepsis-related organ failure assessment (SOFA (show PFAS Proteins)) scores, rs4291, serum ACE and rs4646994 were all considered as risky factors for septic shock (SS) patients. The study demonstrates that TT genotype of rs4291 or DD genotype of rs4646994 may be indicative of a higher risk of SS and a poorer prognosis in SS patients.
high-saturated-fat-diet-induced increase of ACE serum concentrations reveals ACE to be a potential molecular link between dietary fat intake and hypertension and cardiovascular disease (CVD). The GG genotype of the ACE rs4343 polymorphism represents a robust nutrigenetic marker for an unfavorable response to high-saturated-fat diets.
Heterozygous FV Leiden, homozygous PAI-1 4G/4G, heterozygous MTHFR C677T, homozygous MTHFR A1298C, as much as the combined thrombophilic genotypes MTHFR 677T + ACE Iota/D, MTHFR 677T/1298C + ACE D/D, ACE I/D + b-fibrinogen -455 G/A, FV HR2 + b-fibrinogen -455 G/A showed a correlation as risk factors for Recurrent pregnancy loss.
These results suggested that EGCg might allosterically inhibit the ACE activity through oxidative conversion into an electrophilic quinone.
ACE phenotyping provides important information about conformational and kinetic changes in ACE of individual patients, and this could be a reason for resistance to ACE inhibitors in some nonresponders.
conclude ACE I/D polymorphism plays a vital role in predisposition of higher risk for glioma. We also suggest that ACE DD genotypes may act as an important predictive biomarker for overall survival of glioma patients
ACE rs4340 polymorphism is not associated with acute coronary syndrome. ACE rs4340 polymorphism is associated with higher ACE blood levels.
A significant association was found between DD genotype and cIMT (p < 0.005), while no association between ACE genotype and the presence of carotid plaques.
No significant association was found between female, male RHD patients.
The results indicate that the two active sites within bovine somatic ACE exhibit strong negative cooperativity.
Phorbol 12-myristate 13-acetate (PMA) induced Egr-1 and ATF-2 binding to the ACE promoter, whereas Ets-1 binding was suppressed by PMA.
Resveratrol upregulated ACE2 (show ACE2 Proteins) and inhibited abdominal aortic aneurysm growth in a mouse model.
In mice with renal injury induced by L-NAME pretreatment, renal tubular epithelial ACE is essential for renal angiotensin II accumulation and salt-sensitive hypertension
Studied ACE role in peptide processing and for MHC class II antigen presentation; found ACE level effects efficiency of antigen presentation, and overexpression or inhibition of ACE alters the CD4 (show CD4 Proteins)(+) T-cell and antibody response.
ACE enhances the oxidative response and bactericidal activity of neutrophils.
this study shows that angiotensin-converting enzyme inhibitor captopril rescues mice from endotoxin-induced lethal hepatitis
Smooth muscle cell-derived ACE contributes to atherosclerosis, independent of circulating ACE activity and blood pressure.
Intestinal ACE shedding is increased by DSS (show PMP22 Proteins)-induced intestinal inflammation and parallels local corticosterone production. ACE product angiotensin II stimulates corticosterone formation in healthy intestine.
Renin (show REN Proteins) angiostensin system contributes to 20-HETE-mediated microvascular remodeling in hypertension and that 20-HETE-driven microvascular remodeling independent of blood pressure elevation does not fully rely on ACE activity in the vascular endothelium.
angiotensin-converting enzyme has an essential role in hypertension induced by nitric oxide synthesis inhibition
Suggest that the ACE2 (show ACE2 Proteins)-ACE imbalance plays an important role in the pathogenesis of severe acute pancreatitis and that pancreatic ACE2 (show ACE2 Proteins) is an important factor in determining the severity of SAP (show APCS Proteins).
Tissue Ang I (show AGT Proteins)-II conversion depends exclusively on the ACE C-domain, whereas both domains contribute to conversion by soluble ACE and to bradykinin degradation at tissue sites.
The contributions of the C-domain and N-domain differ between DDs and IIs genotype
Corneal cells express ACE, AT(1) and AT(2)receptors. ACE inhibitor enalapril decreased corneal angiogenesis in VEGF (show VEGFA Proteins)-induced corneal neovascularization. ACE inhibitors may be novel therapy to treat corneal angiogenesis.
Angiotensin-converting enzyme (ACE) residues encompassing 343 to 655 of the germinal form are required for its cleavage-secretion.
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
, angiotensin I converting enzyme 1
, CD143 antigen
, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
, angiotensin converting enzyme, somatic isoform
, dipeptidyl carboxypeptidase 1
, dipeptidyl carboxypeptidase I
, kininase II
, peptidase P
, testicular ECA
, Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)
, angiotensin 1 converting enzyme 1
, angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)
, angiotensin I-converting enzyme
, dipeptidyl peptidase
, angiotensin-I converting enzyme
, peptidyl dipeptidase i
, angiotensin converting enzyme
, Angiotensin-converting enzyme, testis-specific isoform
, dipeptidyl carboxy peptidase 1
, Dipeptidyl carboxypeptidase I
, Kininase II