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DD genotype and D allele of ACE gene I/D polymorphism might increase the risk of lymph node metastasis in colorectal cancer patients.
The results suggest that ACE I/D polymorphism, high ACE activity, body mass index and oxidative damage may play key roles in the pathogenesis of preeclampsia in the Mexican population.
SNPs in folate pathway genes MTHFR (show MTHFR Proteins)/ MTR (show MTR Proteins)/ACE and hyperhomocysteinemia have roles in risk of coronary artery disease.
ACE I alleles are associated with dementia risk.
Data indicate it is unlikely that ACE II genotype provides an advantage in endurance running.
This study concludes that DD genotype is strongly associated with higher SBP (show SHBG Proteins) in hypertensive patients.
ACE binds to lysozyme (show LYZ Proteins) and bilirubin, which regulate its conformation and shedding
The presence of the ACE I-allele was associated with increased aerobic functional capacity after the aerobic interval training program.
Study showed that dietary weight loss-induced changes in angiotensin-converting enzyme activity, free fatty acids and RBP4 (show POLR2D Proteins) independently contribute to weight regain prediction.
Among the four haplotypes composed by ACE gene A2350G and I/D, haplotype G-D reached the statistical significance in two groups, and exhibited to be a risk factor for the development of EH, whose P < 0.001 and OR 95%CI = 1.639(1.435-1.872), while the other haplotypes were the protective factors and decreased the susceptibility to EH(P < 0.05).
Resveratrol upregulated ACE2 (show ACE2 Proteins) and inhibited abdominal aortic aneurysm growth in a mouse model.
In mice with renal injury induced by L-NAME pretreatment, renal tubular epithelial ACE is essential for renal angiotensin II accumulation and salt-sensitive hypertension
Studied ACE role in peptide processing and for MHC class II antigen presentation; found ACE level effects efficiency of antigen presentation, and overexpression or inhibition of ACE alters the CD4 (show CD4 Proteins)(+) T-cell and antibody response.
ACE enhances the oxidative response and bactericidal activity of neutrophils.
this study shows that angiotensin-converting enzyme inhibitor captopril rescues mice from endotoxin-induced lethal hepatitis
Smooth muscle cell-derived ACE contributes to atherosclerosis, independent of circulating ACE activity and blood pressure.
Intestinal ACE shedding is increased by DSS (show PMP22 Proteins)-induced intestinal inflammation and parallels local corticosterone production. ACE product angiotensin II stimulates corticosterone formation in healthy intestine.
Renin (show REN Proteins) angiostensin system contributes to 20-HETE-mediated microvascular remodeling in hypertension and that 20-HETE-driven microvascular remodeling independent of blood pressure elevation does not fully rely on ACE activity in the vascular endothelium.
angiotensin-converting enzyme has an essential role in hypertension induced by nitric oxide synthesis inhibition
Suggest that the ACE2 (show ACE2 Proteins)-ACE imbalance plays an important role in the pathogenesis of severe acute pancreatitis and that pancreatic ACE2 (show ACE2 Proteins) is an important factor in determining the severity of SAP (show APCS Proteins).
Tissue Ang I (show AGT Proteins)-II conversion depends exclusively on the ACE C-domain, whereas both domains contribute to conversion by soluble ACE and to bradykinin degradation at tissue sites.
The contributions of the C-domain and N-domain differ between DDs and IIs genotype
Corneal cells express ACE, AT(1) and AT(2)receptors. ACE inhibitor enalapril decreased corneal angiogenesis in VEGF (show VEGFA Proteins)-induced corneal neovascularization. ACE inhibitors may be novel therapy to treat corneal angiogenesis.
Angiotensin-converting enzyme (ACE) residues encompassing 343 to 655 of the germinal form are required for its cleavage-secretion.
a portion of the extracellular region of tACE (show ADAM17 Proteins) (containing its catalytic site) is released from bovine sperm during capacitation, and tACE (show ADAM17 Proteins) activity may be required for sperm capacitation.
The results indicate that the two active sites within bovine somatic ACE exhibit strong negative cooperativity.
Phorbol 12-myristate 13-acetate (PMA) induced Egr-1 and ATF-2 binding to the ACE promoter, whereas Ets-1 binding was suppressed by PMA.
Precompetition angiotensin converting enzyme (ACE) activity in endurance horses competing in an 80 km event was not associated with either finishing position or heart rates, indicating that the enzyme is not a good predictor of performance.
This research investigated angiotensin-converting enzyme activity in the plasma of racehorses and demonstrated that its activity is increased in horses with higher degrees of hemorrhage and is a promising biomarker for pulmonary hemorrhage.
These results show an increase in ACE activity up to fatigue and a return to baseline values at 30 min post exercise.
The aim of this study was to investigate the correlation between angiotensin-converting enzyme (ACE) activity in the equine endometrium and the degree of endometrial periglandular fibrosis.
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
, angiotensin converting enzyme, somatic isoform
, angiotensin-converting enzyme
, dipeptidyl carboxypeptidase 1
, dipeptidyl carboxypeptidase I
, kininase II
, peptidase P
, testicular ECA
, dipeptidyl peptidase
, Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)
, angiotensin 1 converting enzyme 1
, angiotensin I converting enzyme 1
, angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)
, Angiotensin-converting enzyme, testis-specific isoform
, dipeptidyl carboxy peptidase 1
, angiotensin converting enzyme
, angiotensin-I converting enzyme
, peptidyl dipeptidase i
, angiotensin I-converting enzyme
, Dipeptidyl carboxypeptidase I
, Kininase II
, LOW QUALITY PROTEIN: angiotensin-converting enzyme