Angiotensin I Converting Enzyme 1 Protein (AA 1071-1313) (His tag)

Catalog No. ABIN7505530

This Recombinant Angiotensin I Converting Enzyme 1 protein is produced in Escherichia coli (E. coli).

Quick Overview for Angiotensin I Converting Enzyme 1 Protein (AA 1071-1313) (His tag) (ABIN7505530)

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Protein Type: Recombinant

Origin: Rat

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 1071-1313

Purification tag / Conjugate: This Angiotensin I Converting Enzyme 1 protein is labelled with His tag.

Sequence: Phe 1071-Ser 1313

Characteristics: A DNA sequence encoding the Rat ACE protein (P47820) (Phe 1071-Ser 1313) was expressed with N-His tag.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Alternative Name: ACE

Background:

Abbreviation: ACE

Target Synonym: Angiotensin-converting enzyme,Dipeptidyl carboxypeptidase I,Kininase II,CD143,Dcp1

Background: Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin.

Molecular Weight:

Calculated MW: 26.62 kDa

Observed MW: 28 kDa

UniProt: P47820

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration