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These data indicate that Ang II (show AGT Proteins)-AT2R regulates human bone marrow MSC (show MSC Proteins) migration by signaling through the FAK (show PTK2 Proteins) and RhoA (show RHOA Proteins)/Cdc42 (show CDC42 Proteins) pathways.
Low levels of AT2R is associated with angiogenesis in bladder cancer.
angiotensin II type 2 receptor activation in inguinal adipocytes opposes norepinephrine-induced uncoupling protein-1 (UCP1 (show UCP1 Proteins)) production and aspects of cellular respiration
loss of AT2 R is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein (show HHIP Proteins) expression in podocytes
In this genomewide association study, we found that variants at the EBF1 (show EBF1 Proteins), EEFSEC (show EEFSEC Proteins), AGTR2, WNT4 (show WNT4 Proteins), ADCY5 (show ADCY5 Proteins), and RAP2C (show RAP2C Proteins) loci were associated with gestational duration and variants at the EBF1 (show EBF1 Proteins), EEFSEC (show EEFSEC Proteins), and AGTR2 loci with preterm birth.
crystal structures of human AT2R bound to an AT2R-selective ligand and to an AT1R (show AGTR1 Proteins)/AT2R dual ligand, capturing the receptor in an active-like conformation
Suggest a gender-specific association between the AT2R -1332 A/G polymorphism and the occurrence of carotid plaque and the history of cerebrovascular insult in advanced carotid atherosclerosis.
peripheral and central arterial pressures and pulse wave augmentation indexes (AIx(P), AIx(C1), AIx(C2)), pulse wave velocity (PWV), daily urinary sodium excretion were measured and did genetic studies of AGTR1 (show AGTR1 Proteins) A1166C and AGTR2 G1675A polymorphisms.
Significant overrepresentation of AT2R-1332 AA genotype in female multiple sclerosis patients was found, compared to female controls.
These data suggest that AT2R inhibits ligand-induced AT1R signaling through the PKC-dependent pathway.
crosstalk between AT2 receptor stimulation and PPARgamma (show PPARG Proteins) activation could contribute to attenuation of vascular intimal proliferation
Deletion of AT2 receptor reduced SHP-1 (show PTPN6 Proteins) activity and restored VEGF (show VEGFA Proteins) actions, leading to an increased blood flow reperfusion after ischemia in diabetes mellitus.
Our current results reinforce the notion that the AT2R has a physiological role in the conservation of insulin (show INS Proteins) action
Ultra-high doses did not influence the ACE2 (show ACE2 Proteins)/AT2R/Mas (show MAS1 Proteins) axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin (show FN1 Proteins) expression in db/db (show LEPR Proteins) mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage.
This study aimed to define whether sex chromosome complement (SCC (show CYP11A1 Proteins)) may differentially modulate sex differences in relative gene expression of basal Agtr1a (show AGTR1 Proteins), Agtr2, and Mas1 (show MAS1 Proteins) receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
AT2R-dependent interleukin-17 (show IL17A Proteins) production by T lymphocyte is necessary for collateral artery growth.
Altered expression of AT1 and AT2 receptors with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration.
AT2R inhibits adipogenic differentiation in mesenchymal stem cells. Moreover, this inhibitory effect is associated with Wnt10b (show WNT10B Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
These results suggest that nerve growth factor-mediated neurite outgrowth is suppressed by AT2 receptor signaling via the nitric oxide-cyclic GMP (show NT5C2 Proteins)-PKG (show PRKG1 Proteins) pathway.
Luminal ANG II is internalized as a complex with AT1R/AT2R heterodimers to target endoplasmic reticulum in LLC-PK1 cells, where it might trigger intracellular calcium responses.
AT1 (show AGTR1 Proteins) and AT2 receptors heterodimerize and are involved in the angiotensin II effect on SERCA (show ATP2A3 Proteins) in proximal kidney tubules.
AT2 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Glomerular eNOS (show NOS3 Proteins) gene expression was studied during postnatal maturation and AT1 receptor (show AGTRAP Proteins) inhibition.
Data suggest that AGTR2 (and angiotensin-converting enzyme (show ACE Proteins)) mRNA levels are transiently up-regulated in ovarian theca cells during preovulatory period.
data suggest that G alpha(i3), Shc (show SHC1 Proteins), Grb2 (show GRB2 Proteins), Ras, and Raf-1 (show RAF1 Proteins) link Src (show SRC Proteins) to activation of MAPK (show MAPK1 Proteins) and to the AT(2)-dependent increase in eNOS (show NOS3 Proteins) expression in PAECs
Abundance of AGTR2 mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
angiotensin II type-2 receptor
, type-2 angiotensin II receptor
, AT2 receptor
, angiotensin II type 2 receptor
, angiotensin receptor 2
, angiotensin II receptor type 2
, angiotensin type II receptor
, Type-2 angiotensin II receptor
, angiotensin II subtype 2 receptor, AT2