Browse our anti-ATP6AP2 (ATP6AP2) Antibodies

Human ATPase, H+ Transporting, Lysosomal Accessory Protein 2 (ATP6AP2) interaction partners

1. Macula densa (MD) PRR is essential in a novel juxtaglomerular apparatus short-loop feedback mechanism, which is integrated within the classic MD mechanism to control renin synthesis and release and to maintain blood pressure.

2. Results suggest that full-length ATP6AP2 contributes to the assembly of the V-ATPase proton pore and that impairment of this function affects ER homeostasis and PCP signaling.

3. Data show that TMEM9 binds to and facilitates assembly of vacuolar-ATPase (v-ATPase), a vacuolar proton pump, resulting in enhanced vesicular acidification and trafficking

4. Pro renin receptor plays a critical role in endothelial inflammation in response to UA stimulation.

5. The studies data using clinical samples and animal models suggested the significant implication of (Pro)renin receptor in the pathogenesis of diabetic retinopathy, and the potential usefulness of the ribonucleic acid interference molecule as a therapeutic agent to attenuate ocular inflammation and angiogenesis.

6. inactivating mutations of ATP6AP2 are likely oncogenic drivers of Granular cell tumors; genetic link between endosomal pH regulation and tumorigenesis

7. Use transgenic mouse model with overexpression of the human (pro)renin receptor in neurons to demonstrate a novel angiotensin II-independent mechanism mediated by human prorenin and the (pro)renin receptor in the central regulation of blood pressure.

8. Report (pro)renin receptor immunoreactivity in the subfornical organ is increased in hypertensive humans and is significantly correlated with systolic blood pressure.

9. Increased level of s (pro) RR in first trimester may be a marker for predicting gestational diabetes mellitus

10. Soluble (pro)renin receptor is dysregulated in pregnancies affected by diabetes mellitus, but not in preeclampsia.

11. maternal serum concentrations may reflect acceleration of tissue renin-angiotensin system in the placenta and blood pressure severity

12. The aim of this review, is to highlight new insights into the cellular and molecular mechanisms by which PRR may regulate UB branching, terminal differentiation and function of UB-derived collecting ducts, nephron progenitor maintenance, progression of nephrogenesis and normal structural kidney development and function--{REVIEW}

13. Overexpression of PRR is associated with pancreatic ductal adenocarcinoma.

14. the missense mutations in ATP6AP2 lead to impaired V-ATPase assembly and subsequent defects in glycosylation and autophagy.

15. High ATP6AP2 expression is associated with Renal Damage.

16. serum s(P)RR could be used as a marker for atherosclerotic conditions in hemodialysis patients

17. (P)RR may contribute to the homeostatic control of erythropoiesis.

18. Placental (P)RR can be involved in blood pressure regulation via the tissue RAS. On the other hand, plasma s(P)RR may be involved in the pathogenesis of decreased renal function in preeclampsia.

19. the present results suggest that ATP6AP2 rs5918007T might be susceptible factors for Essential Hypertension in Chinese Han population.

20. A mutation in the splice site following exon 2 may affect splicing due to its close proximity to the exon-intron boundary. It was associated with epilepsy, Parkinsonism and intellectual disability in 2 brothers.

Mouse (Murine) ATPase, H+ Transporting, Lysosomal Accessory Protein 2 (ATP6AP2) interaction partners

1. Collecting duct principal cells modulate ENaC activity, urinary Na(+) excretion, and water transport via prorenin receptor.

2. Macula densa (MD) PRR is essential in a novel juxtaglomerular apparatus short-loop feedback mechanism, which is integrated within the classic MD mechanism to control renin synthesis and release and to maintain blood pressure.

3. these data demonstrate that nephron progenitor cell PRR performs essential functions during nephrogenesis via control of hierarchy of genes that regulate critical cellular processes

4. The data of this study showed that over-expression of ATP6AP2 does not affect adult hippocampal neurogenesis, exercise-induced cell proliferation, or dendritic spine densities in the hippocampus. Only a reduced ventricular volume on the gross morphological level was found.

5. Prorenin receptor plays a buffering role in starvation-induced autophagy by affecting the nuclear translocation of TFEB in skeletal muscle.

6. obesity induced sodium retention and elevated SBP are mediated by the PRR-SGK-1- alpha-ENaC pathway independent of Ang II.

7. We conclude that ATP6AP2 is necessary for cell division, cell cycle progression and mitosis. ATP6AP2 also inhibits ciliogenesis, thus promoting proliferation and preventing differentiation

8. the missense mutations in ATP6AP2 lead to impaired V-ATPase assembly and subsequent defects in glycosylation and autophagy.

9. Kidney collecting duct PRR contributes to renal function and blood pressure responses during chronic ANG II infusion by enhancing renin activity, increasing ANG II, and activating ENaC in the distal nephron segments.

10. These results suggest that in vivo the regulation of macroautophagy depends not only on v-H(+)-ATPase-mediated regulation of MTORC1.

11. Ureter bud PRR performs essential functions during UB branching and collecting duct morphogenesis via control of a hierarchy of genes that control UB branching and terminal differentiation of the collecting duct cells.

12. ATP6AP2 disruption leads to cognitive impairment and neurodegeneration, mimicking aspects of the neuropathology associated with ATP6AP2 mutations in humans.

13. These findings demonstrate a cell-autonomous requirement for the PRR within nephron progenitors for progenitor maintenance.

14. Atp6ap2 may form a complex with H+-ATPases in proximal tubule and intercalated cells but that prorenin has no acute effect on H+-ATPase activity in intercalated cells.

15. a novel GLP1R Interacting Protein ATP6ap2

16. Data suggest that high glucose (as in hyperglycemia) decreases autophagy and increases apoptosis in podocytes via activation of (pro)renin receptor (Atp6ap2) and PI3K/Akt/mTOR signaling pathway.

17. ANG II acts via AT1R to upregulate PRR expression both in cultured cells and in DOCA-salt hypertensive mice by increasing CREB binding to the PRR promoter.

18. nephron PRR may be important in water regulation by modulating the AVP/V2R/AQP2 pathway

19. the v-ATPase ATP6AP2 does not appear to have a fusion-promoting role in the formation of phagolysosomes

20. ATPase H+ transporting lysosomal accessory protein 2 is critical for granule cell fate and morphogenesis.

Horse (Equine) ATPase, H+ Transporting, Lysosomal Accessory Protein 2 (ATP6AP2) interaction partners

1. expressed at higher levels in articular osteochondrosis than in control cartilage

Cow (Bovine) ATPase, H+ Transporting, Lysosomal Accessory Protein 2 (ATP6AP2) interaction partners

1. this is the first study to identify the (pro)renin receptor in ovarian cells and to demonstrate the independent role of prorenin in the resumption of oocyte meiosis in cattle.

Zebrafish ATPase, H+ Transporting, Lysosomal Accessory Protein 2 (ATP6AP2) interaction partners

1. knockdown of atp6ap2 and vps33b had an additive negative effect on biliary development.