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Browse our anti-CYP11B2 (CYP11B2) Antibodies

Full name:: anti-Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 Antibodies (CYP11B2)

On www.antibodies-online.com are 53 Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) Antibodies from 11 different suppliers available. Additionally we are shipping CYP11B2 Kits (11) and CYP11B2 Proteins (8) and many more products for this protein. A total of 75 CYP11B2 products are currently listed.

Synonyms:: ALDOS, Cp45as, Cpn2, Cyp11b, Cyp11b-2, Cyp11b3, CYP11BL, CYPXIB2, P-450C18, P450aldo, P450C18, RNCP45AS

list all antibodies	Gene Name	GeneID	UniProt
	CYP11B2	1585	P19099
	CYP11B2	13072	P15539
	CYP11B2	24294
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anti-Human CYP11B2 Antibodies:

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anti-Rat (Rattus) CYP11B2 Antibodies:

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Top referenced anti-CYP11B2 Antibodies

Human Polyclonal CYP11B2 Primary Antibody for WB - ABIN4890921 : Brenner, Labreuche, Pico, Scheltens, Poirier, Cambien, Amarenco: The renin-angiotensin-aldosterone system in cerebral small vessel disease. in Journal of neurology 2008 (PubMed)
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Horse (Equine) Polyclonal CYP11B2 Primary Antibody for WB - ABIN2776971 : Doi, Satoh, Maekawa, Nakamura, Fustin, Tainaka, Hotta, Takahashi, Morimoto, Takase, Ito, Sasano, Okamura: Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism. in The Journal of clinical endocrinology and metabolism 2014 (PubMed)
Human Polyclonal CYP11B2 Primary Antibody for IHC, IHC (p) - ABIN4301715 : Scortegagna, Berthon, Settas, Giannakou, Garcia, Li, James, Liddington, Vilches-Moure, Stratakis, Ronai: The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion. in JCI insight 2017 (PubMed)

More Antibodies against CYP11B2 Interaction Partners

Human Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) interaction partners

Hybrid gene (8q24.3) due to unequal crossing (8q24.3) over cause Na over reabsorption in the distal nephron and volume expansion leading to Monogenic Hypertension Syndrome in children.
The research reveals that among patients with essential hypertension treated with hypotensive drugs there are certain relationships between the rs5182 and rs5186 polymorphisms of the AGTR1 gene, as well as between the rs1799998 polymorphism of the CYP11B2 gene and the volume of the carotid bodies.
Frequencies and distribution of genotype TT of CYP11B2 (C-344T) gene polymorphism among South African Black women, especially those without HIV infection, may prevent them from developing preeclampsia.
Aldosterone-producing adenomas (APAs) exhibit different patterns of CYP11B2 staining that vary from uniform to homogeneous. Approximately 30% of patients with unilateral hyperaldosteronism do not have an APA, but either have an increased number of CYP11B2 expressing micronodules or hyperplasia of the zona glomerulosa. [review]
In conclusion, our meta-analysis indicated that subjects with TT genotype might have higher risk of developing LVH in northern Han Chinese.
study demonstrated significant genetic interaction on Na intake with child obesity by salt-sensitive genes variations, NEDD4L and CYP11beta2
The combination of the V386A mutation with the variant CYP11B2 173(Arg) only slightly reduces the 18-hydroxylase and 18-oxidase activity, whereas the V386A mutation with the CYP11B2 173(Lys) variant almost abolishes the 18-hydroxylation and 18-oxidation. In both cases the 11-hydroxylase activity is not affected.
The AG genotype frequency of single nucleotide polymorphism rs542092383 was significantly associated with an increased risk of Essential Hypertension among northern Han Chinese.
the cellular distribution of CYP11B2, CYP11B1, CYP17A1 and KCNJ5 in adrenals from two familial hyperaldosteronism type 3 siblings, was examined.
Aging is associated with a pattern of decreased normal zona glomerulosa CYP11B2 expression.
CYP11B2 methylation was found in patients with aldosterone producing adenomas.
In European continental ancestry patients the C allele (CC or CT) at -344T/C SNP in the aldosterone synthase gene does not significantly influence clinical prognosis of chronic heart failure.
Data suggest that binding sites between CYP11B1/CYP11B2 and adrenodoxin/ferredoxin-1 exhibit electrostatic interactions at K370 in CYP11B1 and at K366 in CYP11B2 mutant R366K with D79 in adrenodoxin/ferredoxin-1. (CYP11B1 = cytochrome P450 family 11 subfamily B member 1; CYP11B2 = cytochrome P450 family 11 subfamily B member 2)
his study provided candidates for novel drug-like CYP11B2 inhibitors by molecular simulation methods for the hypertension treatment.
Suggest that there is lack of association between -344T/C polymorphism of CYP11B2 gene and coronary heart disease in Malaysian population.
Our study is aimed at evaluating the contribution of CYP11B2 promoter methylation to the risk of essential hypertension(EH). Our findings suggest that gene-environment interactions are associated with the pathogenesis and progression of EH
The present study revealed a strong synergistic effect of CYP11B2 C-344T and IC polymorphisms causing susceptibility to EHT and haplotype H1 (-344T-Conv-Lys173) as the risk-conferring factor for hypertension predisposition.
Deletions, duplications or chimeric CYP11B2/CYP11B1 gene is associated with 11beta-hydroxylase deficiency.
CYP11B2 T-344C single nucleotide polymorphism exhibited a strong association with the development of coronary artery disease in Taiwanese women.
aldosterone synthase (CYP11B2) gene polymorphism may contribute to diabetic nephropathy development, especially in Asian group, with the T allele acting as a risk factor.

Mouse (Murine) Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) interaction partners

Aldosterone synthase knockout mouse shows odium-induced endothelial sodium channel up-regulation in vascular endothelium
Aldosterone synthase (CYP11B2) is a key regulator of fibrotic remodeling during atrial fibrillation.
Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1
Modest increase in aldosterone synthase (AS) expression makes blood pressure more sensitive to salt in mice, suggesting that genetically increased AS expression in humans may contribute to hypertension and cardiovascular complication with high-salt diets.

Cow (Bovine) Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) interaction partners

Fetal adrenal cells in primary culture respond to angiotensin-II (or synthetic ACTH) by increasing aldosterone production and aldosterone synthase [P450c18/CYP11B2] activity.

CYP11B2 Antigen Profile

Antigen Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.

Alternative names and synonyms associated with CYP11B2

cytochrome P450 family 11 subfamily B member 2 (CYP11B2) antibody
cytochrome P450, family 11, subfamily b, polypeptide 2 (Cyp11b2) antibody
aldosterone synthase (Cyp11b2) antibody
cytochrome P450, family 11, subfamily B, polypeptide 2 (CYP11B2) antibody
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 (CYP11B2) antibody

ALDOS antibody
Cp45as antibody
Cpn2 antibody
Cyp11b antibody
Cyp11b-2 antibody
Cyp11b3 antibody
CYP11BL antibody
CYPXIB2 antibody
P-450C18 antibody
P450aldo antibody
P450C18 antibody
RNCP45AS antibody

Protein level used designations for CYP11B2

, , , , , , , , , , , , , , , , , , , , , , , , aldosterone synthase aldosterone-synthesizing enzyme cytochrome P-450Aldo cytochrome P-450C18 cytochrome P450 11B2, mitochondrial cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2 steroid 11-beta-monooxygenase steroid 11-beta/18-hydroxylase steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo CYPXIB2 cytochrome P450C11 steroid 11-beta-hydroxylase steroid-11-beta-hydroxylase CYPXIB3 Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase) Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase) P450-Aldo-1 P450-Aldo-2 cytochrome P450 11B3, mitochondrial cytochrome P450, subfamily 11B, polypeptide 2 cytochrome P450-Aldo-1 cytochrome P450-Aldo-2 mitochondrial cytochrome P450 11B2 cytochrome P450, family 11, subfamily B, polypeptide 2

GENE ID	SPECIES
1585	Homo sapiens
13072	Mus musculus
100379213	Cavia porcellus
24294	Rattus norvegicus
482071	Canis lupus familiaris
695914	Macaca mulatta
100328543	Oryctolagus cuniculus
282423	Bos taurus

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Show all anti-Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) Antibodies with Pubmed References