CYP11B2 antibody (Middle Region)

Catalog No. ABIN2776971

Product Details anti-CYP11B2 Antibody

Target: CYP11B2 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2))

Binding Specificity: Middle Region

Reactivity: Human, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP11B2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RRLAEAEMLL LLHHVLKHFL VETLTQEDIK MVYSFILRPG TSPLLTFRAI

Predicted Reactivity: Horse: 79%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CYP11B2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CYP11B2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 503 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CYP11B2 antibody (ABIN2776971)

Doi, Satoh, Maekawa, Nakamura, Fustin, Tainaka, Hotta, Takahashi, Morimoto, Takase, Ito, Sasano, Okamura: "Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism." in: The Journal of clinical endocrinology and metabolism, Vol. 99, Issue 2, pp. E257-62, (2014) (PubMed).

Target Details for CYP11B2

Target: CYP11B2 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2))

Alternative Name: CYP11B2 (CYP11B2 Products)

Synonyms: ALDOS antibody, CPN2 antibody, CYP11B antibody, CYP11BL antibody, CYPXIB2 antibody, P-450C18 antibody, P450C18 antibody, P450aldo antibody, Cpn2 antibody, Cyp11b antibody, Cyp11b-2 antibody, Cp45as antibody, Cyp11b3 antibody, RNCP45AS antibody, cytochrome P450 family 11 subfamily B member 2 antibody, cytochrome P450, family 11, subfamily b, polypeptide 2 antibody, aldosterone synthase antibody, cytochrome P450, family 11, subfamily B, polypeptide 2 antibody, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 antibody, CYP11B2 antibody, Cyp11b2 antibody

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein local
Alias Symbols: ALDOS, CPN2, CYP11B, CYP11BL, P-450C18, P450C18, P450aldo
Protein Interaction Partner: CYP11B2, CYP11B1, CYP11A1, FDX1,
Protein Size: 503

Molecular Weight: 55 kDa

Gene ID: 1585

NCBI Accession: NM_000498, NP_000489

UniProt: P19099

Pathways: ACE Inhibitor Pathway, Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, C21-Steroid Hormone Metabolic Process, Feeding Behaviour