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study demonstrated significant genetic interaction on Na intake with child obesity by salt-sensitive genes variations, NEDD4L (show NEDD4L Proteins) and CYP11beta2
The combination of the V386A mutation with the variant CYP11B2 173(Arg) only slightly reduces the 18-hydroxylase and 18-oxidase activity, whereas the V386A mutation with the CYP11B2 173(Lys (show LYZ Proteins)) variant almost abolishes the 18-hydroxylation and 18-oxidation. In both cases the 11-hydroxylase activity is not affected.
The AG genotype frequency of single nucleotide polymorphism rs542092383 was significantly associated with an increased risk of Essential Hypertension among northern Han Chinese.
the cellular distribution of CYP11B2, CYP11B1 (show CYP11B1 Proteins), CYP17A1 (show CYP17A1 Proteins) and KCNJ5 (show KCNJ5 Proteins) in adrenals from two familial hyperaldosteronism type 3 siblings, was examined.
Aging is associated with a pattern of decreased normal zona glomerulosa CYP11B2 expression.
CYP11B2 methylation was found in patients with aldosterone producing adenomas.
In European continental ancestry patients the C allele (CC or CT) at -344T/C SNP in the aldosterone synthase gene does not significantly influence clinical prognosis of chronic heart failure.
Data suggest that binding sites between CYP11B1/CYP11B2 and adrenodoxin/ferredoxin-1 exhibit electrostatic interactions at K370 in CYP11B1 and at K366 in CYP11B2 mutant R366K with D79 in adrenodoxin/ferredoxin-1. (CYP11B1 = cytochrome P450 family 11 subfamily B member 1; CYP11B2 = cytochrome P450 family 11 subfamily B member 2)
his study provided candidates for novel drug-like CYP11B2 inhibitors by molecular simulation methods for the hypertension treatment.
Suggest that there is lack of association between -344T/C polymorphism of CYP11B2 gene and coronary heart disease in Malaysian population.
Aldosterone synthase knockout mouse shows odium-induced endothelial sodium channel up-regulation in vascular endothelium
Aldosterone synthase (CYP11B2) is a key regulator of fibrotic remodeling during atrial fibrillation.
Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1 (show NR5A1 Proteins)
Modest increase in aldosterone synthase (AS) expression makes blood pressure more sensitive to salt in mice, suggesting that genetically increased AS expression in humans may contribute to hypertension and cardiovascular complication with high-salt diets.
Data show that cytochrome P450 enzymes Cyp17 (show CYP17A1 Proteins)-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Proteins) Foxl2a were detected both in the testis and ovary.
Fetal adrenal cells in primary culture respond to angiotensin-II (or synthetic ACTH (show POMC Proteins)) by increasing aldosterone production and aldosterone synthase [P450c18/CYP11B2] activity.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
, aldosterone-synthesizing enzyme
, cytochrome P-450Aldo
, cytochrome P-450C18
, cytochrome P450 11B2, mitochondrial
, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2
, mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2
, steroid 11-beta-monooxygenase
, steroid 11-beta/18-hydroxylase
, steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
, cytochrome P450C11
, steroid 11-beta-hydroxylase
, Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase)
, Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)
, cytochrome P450 11B3, mitochondrial
, cytochrome P450, subfamily 11B, polypeptide 2
, cytochrome P450-Aldo-1
, cytochrome P450-Aldo-2
, mitochondrial cytochrome P450 11B2
, cytochrome P450, family 11, subfamily B, polypeptide 2
, cytochrome P45011B