Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Results show negative regulation of HDAC1 (show HDAC1 Proteins) by a Cul3 (show CUL3 Proteins)-REN (show REN1 Proteins) E3 ubiquitin ligase (show MUL1 Proteins) complex.
REN (show REN1 Proteins) is upregulated by neurogenic signals (retinoic acid, EGF (show EGF Proteins), and NGF (show NGFB Proteins)) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
REN (show REN1 Proteins) protein enhances caspase-3 (show CASP3 Proteins) activation and antagonizes the Shh (show SHH Proteins) pathway suggesting that this gene may represent a restraint of Shh (show SHH Proteins) signaling.
The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China.
Plasma renin activity is associated with cardiovascular mortality or heart failure readmissions.
In patients with established atherosclerotic disease undergoing carotid endarterectomy, plasma renin and aldosterone concentrations were not associated with atherosclerotic plaque characteristics. Plasma renin concentration was positively associated with the occurrence of major secondary vascular events.
These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development
The genotypes of REN, AT1R (show AGTR1 Proteins) and AT2R (show AGTR2 Proteins) were not associated with the development of preeclampsia in South African Black women.
Urinary angiotensinogen (show AGT Proteins) and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR (show EGFR Proteins) and these associations are independent of urinary albumin (show ALB Proteins) excretion
Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen (show AGT Proteins) and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease.
Prospective study of consecutive cardiac disease patients referred for cardiac catheterization has revealed distinct cardiac disease condition-associated differences in the frequencies of elevations in plasma renin, plasma aldosterone concentration, and the aldosterone-renin ratio
Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF (show VEGFA Proteins).
Data suggest mild primary aldosteronism (PA), where plasma renin activity is not as suppressed, is susceptible to dietary sodium influences on renin and ARR (show SAG Proteins) (aldosterone to renin ratio). Optimal screening for PA should occur under conditions of high dietary sodium intake (rather than condition of low dietary sodium intake as frequently prescribed for patients with hypertension, which may be a symptom of PA).
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
, BTB/POZ domain-containing protein KCTD11
, retinoic acid, EGF, and NGF upregulated
, renin 1 structural
, angiotensin-forming enzyme
, renin precursor, renal