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anti-Human LRRC32 Antibodies:
anti-Mouse (Murine) LRRC32 Antibodies:
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Human Monoclonal LRRC32 Primary Antibody for ELISA, IP - ABIN4230471
Tran, Shevach: Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells. in Human immunology 2009
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Human Polyclonal LRRC32 Primary Antibody for FACS, WB - ABIN4331580
Macaulay, Thon, Tijssen, Steele, MacDonald, Meade, Burns, Rendon, Salunkhe, Murphy, Bennett, Watkins, He, Fitzgerald, Italiano, Maguire: Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. in Blood 2013
Show all 2 Pubmed References
Human Monoclonal LRRC32 Primary Antibody for WB - ABIN1981876
Wang, Zhu, Dong, Shi, Lu, Springer: GARP regulates the bioavailability and activation of TGF?. in Molecular biology of the cell 2012
Human Monoclonal LRRC32 Primary Antibody for CyTOF, FACS - ABIN4900811
Zhang, Robinson, Duverger, Kutsch, Heath, Cron: Regulatory CD4 T cells inhibit HIV-1 expression of other CD4 T cell subsets via interactions with cell surface regulatory proteins. in Virology 2018
Human Polyclonal LRRC32 Primary Antibody for ICC, IF - ABIN5951910
Li, Sun, Yang, Sun, Wu, Zhou, Yu, Bi: Effect of GARP on osteogenic differentiation of bone marrow mesenchymal stem cells via the regulation of TGFβ1 in vitro. in PeerJ 2019
Our findings reveal that GARP, as an immunoregulatory molecule, is located on, as well as in, tumor cells of GB and low-grade glioma, inhibiting effector T cell function, and thus contributing to the immunosuppressive tumor microenvironment of primary brain tumors.
Study demonstrated that B cells are required for the induction of oral tolerance of T cell-dependent antigens via GARP and revealed for the first time that cell surface GARP-TGF-beta is an important checkpoint for regulating B cell peripheral tolerance, highlighting a mechanism of autoimmune disease pathogenesis.
This review summarizes the most important features of GARP biology described to date including gene regulation, protein expression and mechanism in activating latent TGF-beta, and the function of GARP in regulatory T cell biology and peripheral tolerance, as well as GARP's increasingly recognized roles in platelet-mediated cancer immune evasion. [review]
Increased GARP expression in papillary thyroid cancer was positively correlated with increased expression of Foxp3, which is very important for development of Tregs. But, there is no significant association of elevated expression of GARP with lymph node metastasis in papillary thyroid cancer.
This finding reveals how GARP exploits an unusual medley of interactions, including fold complementation by the amino terminus of TGF-beta1, to chaperone and orient the cytokine for binding and activation by alphaVbeta8.
GARP is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta releasing [review]
Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma.
High GARP expression is associated with pancreatic cancer and liver metastases from colorectal cancer.
study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production.
GARP plays an important role in the pathogenesis of atopic dermatitis.
CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype.
these results define the oncogenic effects of the GARP-TGFbeta axis in the tumor microenvironment
LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing
GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction.
since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb
GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells.
we investigated in detail miR-142-3 pregulation of GARP expression in regulatory CD25(+) CD4 T cells
Findings support the idea that GARP is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta and provides a cell surface platform for alphaV integrin-dependent TGFbeta activation.
There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels
GARP is a key receptor controlling FOXP3 in T(reg) cells following T-cell activation in a positive feedback loop assisted by LGALS3 and LGMN
Data (including data from studies using knockout mice) suggest that Garp/Lrrc32 is involved in up-regulation of Tgfb3 and is essential for normal embryogenesis of palate; knockout of Garp causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Tgfb3 = transforming growth factor beta 3; Smad2 = MAD homolog protein 2)
These results demonstrate the unexpected presence of GARP on Hepatic stellate cells and its significance in regard to the ability of Hepatic stellate cells to activate latent TGF-beta1 and thereby inhibit T cells.
GARP expression on MSCs contributed to their ability to inhibit T-cell responses in vitro.
We conclude that a missense mutation in VPS54, an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction.
These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-beta and signaling, which negatively regulates GARP expression on Tregs.
GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
leucine rich repeat containing 32
, leucine-rich repeat-containing protein 32
, leucine-rich repeat-containing protein 32-like
, glycoprotein A repetitions predominant