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anti-Rat (Rattus) TNFSF9 Antibodies:
anti-Mouse (Murine) TNFSF9 Antibodies:
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Human Monoclonal TNFSF9 Primary Antibody for FACS - ABIN2688965
Chu, DeBenedette, Stiernholm, Barber, Watts: Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells. in Journal of immunology (Baltimore, Md. : 1950) 1997
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Mouse (Murine) Monoclonal TNFSF9 Primary Antibody for BR, FACS - ABIN2688839
Akiba, Miyahira, Atsuta, Takeda, Nohara, Futagawa, Matsuda, Aoki, Yagita, Okumura: Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. in The Journal of experimental medicine 2000
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Human Monoclonal TNFSF9 Primary Antibody for ELISA, FACS - ABIN610414
Hutton, Christofori, Chi, Edman, Guest, Hanahan, Kelly: Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue. in Molecular endocrinology (Baltimore, Md.) 1994
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Human Monoclonal TNFSF9 Primary Antibody for ICC, FACS - ABIN1169256
Gullo, Koh, Pang, Ho, Tan, Schwarz: Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling. in PLoS ONE 2010
Human Polyclonal TNFSF9 Primary Antibody for FACS, WB - ABIN4900477
Gilbreth, Oganesyan, Amdouni, Novarra, Grinberg, Barnes, Baca: Crystal structure of the human 4-1BB/4-1BBL complex. in The Journal of biological chemistry 2018
Human Polyclonal TNFSF9 Primary Antibody for CyTOF, FACS - ABIN4900479
Ek, Björck, Högerkorp, Nordenskjöld, Porwit-MacDonald, Borrebaeck: Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival. in International journal of cancer 2006
indicate that spinal cord CD137L contributes to the development of peripheral nerve injury-induced neuropathic pain
m4-1BBL and Gal-9 act together to aid aggregation of m4-1BB monomers to efficiently initiate m4-1BB signaling.
the CD137-CD137L pathway plays an important role in regulating VSMC phenotype transformation via activation of NFATc1 signaling pathway.
this study shows that intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung
the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L was further investigated.
Data indicate that anti-CD137 agonists can function as inhibitors of CD137L signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.
Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody.
4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues
These results demonstrate that 4-1BBL-engineered DCs can improve CIKs cytotoxicity against prostate cancer cells.
these observations suggest that inhibition of the TLR/4-1BBL complex formation may be highly efficient in protecting against continued inflammation
4-1BB mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.
CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis.
Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions.
monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB, and in conjunction with this pathway, maintain their numbers at baseline.
CD137-expressing CD4+ T cells in the bone marrow engage CD137L on hematopoietic progenitor cells, and this CD137L signaling biases hematopoiesis towards myelopoiesis during aging.
TIRAP and IRAK2 are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4-1BBL complex.
Results suggest that CD137L reverse signaling exerts a pro-apoptotic effect by suppressing integrin-mediated survival signals in neural stem cells.
CD137-CD137L interactions increase myelopoiesis during infection
4-1BB/4-1BBL-mediated bidirectional signaling in adipocytes/macrophages promotes adipose inflammation.
A VCAM-1-positive stromal cell is a plausible candidate for the radioresistant cell that provides 4-1BB ligand to sustain memory CD8-positive T cells.
A comparison with the human 4-1BB/4-1BBL complex highlighted several differences between the ligand- and receptor-binding interfaces, providing an explanation for the absence of inter-species cross-reactivity between human and mouse 4-1BB and 4-1BBL molecules.
We clarified the role of CD137L in osteosarcomagenesis and its potential therapeutic application. Our transcriptome analysis also indicated the regulation of the immune response through p53.
structural and functional properties of both h4-1BB and h4-1BBL and reveals that covalent receptor dimerization amplifies h4-1BB signaling
CD137L-dendritic cells (CD137L-DCs) express high levels of adhesion molecules, display strong attachment.
TNFSF9 exerts an inhibitory effect on hepatocellular carcinoma and may be a tumor suppressor.
4-1BB and 4-1BBL qualify as markers for prediction of patients' course and represent a valuable screening target for patients with acute myeloid leukemia at initial diagnosis.
the results from this study show that the costimulatory 4-1BB ligand fortifies an antigen-rich melanoma cell line with enhanced antigen-specific stimulation of CD8 T cells
blocking of both OX-40L and 4-1BBL reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.
CD137L is overexpressed in non-small cell lung cancer specimens and positive expression of CD137L was associated with better overall survival.
In vitro immunotherapy is described for anti-prostate cancer effects of cytotoxic T lymphocytes induction by recombinant adenovirus mediated PSMA/4-1BBL dendritic cells.
vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3+CD8+ TIL and NK cells, decreased the number of FOXP3 cells and inhibited the development of DMH-induced colorectal cancer
Elevated plasma levels and monocyte-associated expression of CD137 ligand in patients with acute atherothrombotic stroke
Hence, the targeted combination of IL-15 and 4-BBL in the form of a trifunctional antibody-fusion protein is a promising new approach for cancer immunotherapy.
this is the first study to indicate that this member of the TNF superfamily, CD137, is modulated by SAHA treatment in breast
Data show that TNFR1 associates with CD137L and is required for CD137L reverse signaling.
CD137L is a novel diagnostic marker of subtypes of non-Hodgkin B-cell lymphomas.
signaling through CD137L in non-hematopoietic cells such as epithelial cells and endothelial cells has been shown to play an essential role in sterile inflammation by regulating immune cell recruitment. [Review]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
, tumor necrosis factor (ligand) superfamily, member 9
, 4-1BB ligand
, tumor necrosis factor ligand superfamily member 9
, homolog of mouse 4-1BB-L
, receptor 4-1BB ligand