Protein Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Alternative names and synonyms associated with TNFSF9

• TNF superfamily member 9 (Tnfsf9) antibody
• TNF superfamily member 9 (LOC476729) antibody
• TNF superfamily member 9 (TNFSF9) antibody
• tumor necrosis factor (ligand) superfamily, member 9 (Tnfsf9) antibody

• 4-1BB-L antibody
• 4-1BBL antibody
• AI848817 antibody
• CD137L antibody
• Ly63l antibody
• Show all synonym aliases
• TNFSF9 antibody

Protein level used designations for TNFSF9

costimulatory molecule , tumor necrosis factor (ligand) superfamily, member 9 , 4-1BB ligand , tumor necrosis factor ligand superfamily member 9 , 4-1BBL , homolog of mouse 4-1BB-L , receptor 4-1BB ligand