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anti-Human COLEC12 Antibodies:
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Human Polyclonal COLEC12 Primary Antibody for BR, FACS - ABIN5012874
Keuschnigg, Karinen, Auvinen, Irjala, Mpindi, Kallioniemi, Hautaniemi, Jalkanen, Salmi: Plasticity of blood- and lymphatic endothelial cells and marker identification. in PLoS ONE 2014
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Mouse (Murine) Polyclonal COLEC12 Primary Antibody for BR, FACS - ABIN5012875
Tran, Ahern, Hodge, Holt, Dean, Reynolds, Hodge: Oxidative stress decreases functional airway mannose binding lectin in COPD. in PLoS ONE 2014
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CL-P1 is a novel receptor involved in myelin uptake by phagocytes and likely plays a role in multiple sclerosis lesion development.
rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes
The common presence of Lewis(x) groups in granule protein glycans can thus target granule proteins for clearance by SRCL.
The Le(x) residues of both, CEACAM1 and CEA, interact with the human Le(x)-binding glycan receptors DC-SIGN and SRCL.
haplotype structure of the CL-P1 gene obtained from six single-nucleotide polymorphisms that were genotyped with 108 alleles in Japanese subjects
SRCL is expressed in some but not all nurse-like cells; its C-type lectin domain binds specifically to several carbohydrates including GalNAc, T and Tn antigen in a Ca2+-dependent manner.
SRCL might be involved in selective clearance of specific desialylated glycoproteins from circulation and/or interaction of cells bearing Lewis(x)-type structures with the vascular endothelium
CL-P1 is not a common membrane protein on endothelial cells found in normal tissues under steady state conditions.
CL-P1 predominantly mediated phagocytosis for fungi in vascular endothelia.
Structural analysis of carbohydrate-recognition domain of SRCL in complex with Lewis(x) and mutagenesis show the basis for this specificity, which is analogous to how selectins and DC-SIGN bind to related fucosylated glycans [scavenger receptor C]
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells.
collectin sub-family member 12
, collectin placenta protein 1
, nurse cell scavenger receptor 2
, scavenger receptor class A, member 4
, scavenger receptor with C-type lectin
, collectin 1 precursor CL-3