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Human PGLYRP2 Protein expressed in HEK-293 Cells - ABIN2728787
Hua, Yuan, Li, Coursey, Pflugfelder, Li: A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins. in PLoS ONE 2015
We identified and cloned three zebrafish Peptidoglycan recognition proteins, PGLYRP-2, PGLYRP-5, and PGLYRP-6, and showed that they are highly expressed in eggs, developing embryos, and adult tissues that contact external environment
single nucleotide polymorphisms in PGLYRP-2 gene were related to mastitis resistance and percentage of fat
a significant induction of three PGLYRPs 2-4 in primary human corneal epithelial cells (HCECs) exposed to live or heat-killed Candida albicans, is reported.
This study demonistrated that PGLYRP2 single-nucleotide polymorphisms is risk of Parkinson's disease.
Various types of human blood cells were tested for expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which belong to the family of proteins possessing the lysozyme-like peptidoglycan recognition protein (PGRP) domain
Serum N-acetylmuramoyl-l-alanine amidaseand liver PGLYRP2 are the same protein encoded by the pglyrp2 gene.
PGLYRP2 may function in the skin and the eyes as an inducible scavenger of proinflammatory peptidoglycan.
pglyrp2 expression in skin and liver is important for systemic and local innate immune responses to bacterial infections
Study shows sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel role for Pglyrp2 as a key regulator of motor and anxiety-like behavior in late life.
Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice
Nod2(-/-) Pglyrp2(-/-) mice displayed increased susceptibility to infection at 24 h postinfection compared to Pglyrp2(-/-). Thus, PGLYRP2 plays a protective role in vivo in the control of S. Typhimurium infection through a Nod1/Nod2-independent mechanism.
Pglyrp2 limits overactivation of Th17 cells by promoting accumulation of regulatory T cells at the site of inflammation in an experimentally induced mouse model of psoriasis
role in regulation of the enteric host-microbe homeostasis
In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi.
substantially impaired Listeria monocytogenes invasion and early intracellular growth in human epithelial cells. [TagL]
The authors demonstrate that PGLYRP-2 and Nod2 are both required for arthritis in the peptidoglycan-induced arthritis model in mice.
overexpression of pPGRP-L1 or pPGRP-L2 dramatically upregulates expression of beta-defensin-1
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments.
, long peptidoglycan recognition protein
, peptidoglycan recognition protein 2
, peptidoglycan recognition protein L
, peptidoglycan recognition protein L-like
, N-acetylmuramoyl-L-alanine amidase-like
, peptidoglycan recognition protein long