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This gene encodes a secreted peptide that displays antimicrobial (show REG3A Proteins)activity against Gram-positive bacteria.
a model of CagA (show S100A8 Proteins)-directed REG3gamma expression in gastric epithelial cells via activation of the IL-11 (show IL11 Proteins)/gp130 (show IL6ST Proteins)/STAT3 (show STAT3 Proteins) pathway
REG III (show REG3A Proteins) was identified and expressed predominantly in pancreas and testis, but not in small intestine
PAP IB represents a good example of duplication and divergence, probably with the acquisition of new functions, thus participating in the evolution of the protein repertoire.
Reg3g acts as an immunosuppressive promoter by activating the JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
The study shows that cardiac stress activates Reg3gamma expression and p38 MAPK (show MAPK14 Proteins) is an upstream regulator of Reg3gamma gene expression in heart. Altogether the data suggest Reg3gamma is associated with cardiac inflammatory signaling.
Recombinant IFN-I or IFN-I expression induced by RIG-I (show DDX58 Proteins) promoted growth of intestinal organoids in vitro and production of the antimicrobial peptide (show CAMP Proteins) regenerating islet-derived protein 3 gamma (RegIIIgamma).
Intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver.
Administration of vancomycin downregulates RegIIIgamma and IL-17 (show IL17A Proteins) expression in skin wounds.
antibacterial function for lung epithelium through Stat3 (show STAT3 Proteins)-mediated induction of Reg3gamma.
Expression of Reg3 (show REG3A Proteins) proteins and Ang4 (show ANGPT4 Proteins) by goblet cells point to an important role for goblet cells in innate defense.
Reg (show KCNH2 Proteins)-IIIgamma expression is mainly observed in epithelial cells of the airways and intestine, but not in the nervous system; expression levels show a gradually increasing pattern along with development.
Letter: aggregation status of PAP1 and PAP2 (show MYBBP1A Proteins) could change their role in regulating the inflammation in acute pancreatitis.
Expression of Reg (show KCNH2 Proteins) proteins in embryonic stem cells is modulated by Wnt (show WNT2 Proteins)/beta catenin (show CTNNB1 Proteins) signaling.
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antibacterial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
, pancreatitis-associated protein 1B
, pancreatitis-associated protein IB
, reg III-gamma
, regenerating gene III
, regenerating islet-derived protein 3-gamma
, regenerating islet-derived protein III-gamma
, RegIII (gamma)
, generating islet-derived, mouse homolog 3 gamma
, pancreatitis-associated protein 3
, regenerating islet-derived protein 3 gamma
, regenerating islet-derived family member 3
, pancreatic thread protein
, regenerating islet-derived 3 alpha