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Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation
Review/Meta-analysis: genetic polymorphisms in leptin, adiponectin and their receptors affect the development and progression of prostate cancer.
Renoprotection of adiponectin is associated with improvement of the endothelial dysfunction, reduction of oxidative stress, and upregulation of endothelial nitric oxide synthase (show NOS3 Proteins) expression through activation of adenosine 5'-monophosphate-activated protein kinase (show CDK7 Proteins) by AdipoR1 and activation of peroxisome proliferator-activated receptor (show PPARD Proteins) (PPAR)-alpha (show PPARA Proteins) signaling pathway by AdipoR2 (show ADIPOR2 Proteins). [review]
High ADIPOR1 expression is associated with breast cancer.
revised ADIPOR1 crystal structure exhibiting a seven-transmembrane-domain architecture that is clearly distinct from that of ADIPOR2 (show ADIPOR2 Proteins)
TNF-alpha (show TNF Proteins) impairs adiponectin/AdipoR1 signaling, mitochondrial biogenesis, and myogenesis in primary human myotubes cultures obtained from heart failure patients.
the knockdown phenotype was partially rescued by injecting wild-type, but not mutant, human ADIPOR1 mRNA. We conclude that ADIPOR1 is a novel adRP (show PLIN2 Proteins)-causing gene and plays an important role in rod development and maintenance.
Adiponectin stimulates cPLA2 and COX-2 expression via AdipoR1/2-dependent activation of PKC/NADPH oxidase/mitochondria resulting in ROS accumulation, p300 phosphorylation, and histone H4 acetylation.
Decreased expression of ADIPOR1 is associated with polycystic ovary syndrome.
sequence- and structure-based computational tools were employed in this study to functionally and structurally characterize the coding Nonsynonymous Single Nucleotide Polymorphisms of ADIPOR1 gene listed in the single nucleotide polymorphisms database.
PCR results showed expression of adiponectin, AdipoR1, AdipoR2 (show ADIPOR2 Proteins), follicle-stimulating hormone receptor (FSHR (show FSHR Proteins)), and luteinizing hormone receptor (LHR (show LHCGR Proteins)) in granulosa cells (GCs (show GCLC Proteins)). After controlling body mass index (BMI) values, qRT-PCR demonstrated a decreased expression of adiponectin system in GCs (show GCLC Proteins) of polycystic ovary syndromepatients compared to those in controls
although the physiological levels of adiponectin are sufficient to activate AMPK and Akt when AdipoR1 is overexpressed in beta-cells, yet adiponectin cannot protect beta-cells in Akita mice from ER stress-induced destruction
Immunofluorescence indicated that GPRC6A and adiponectin receptor 1 were co-localized in mouse muscle tissues. The present finding suggested adiponectin receptor 1 can mediate the improvement of glucose metabolism by osteocalcin (show BGLAP Proteins) in ovariectomized mice
adiponectin maintains intestinal homeostasis and protects against murine colitis through interactions with its receptor AdipoR1 and by modulating adaptive immunity and STAT3 (show STAT3 Proteins) signaling
Based on these findings, this study showed that CTRP9 might induce mitochondrial biogenesis and protect high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1alpha signaling pathway.
High salt is an important suppressor of cardioprotective APN (show ANPEP Proteins) and AdipoR1 in cardiac myocytes.
AdipoR1, not AdipoR2 (show ADIPOR2 Proteins), was first identified as a receptor of CTRP6 during the process of mitotic clonal expansion. Collectively, we suggest that CTRP6 mediates the ectopic lipogenesis through AdipoR1/Erk (show EPHB2 Proteins)/PPARgamma (show PPARG Proteins) signaling pathway in myoblasts.
The results demonstrated a dynamic dysfunction of APN (show ANPEP Proteins)/AdipoR1 axis accompanying progression of diabetes mellitus in mice with cerebral ischemia.
physiologic adiponectin levels enhance the vasorelaxative response to acetylcholine by inducing nitric oxide production through AdipoR1/Cav-1 (show CAV1 Proteins) mediated signaling.
AdipoR1 is expressed on adipose tissue-resident Tregs, mainly Helios (show ZNFN1A2 Proteins)(+) Tregs, and this expression is dependent on weight and fat accumulation. This data proposes a new mechanism through which weight gain might alter immunoregulation.
Adiponectin directly acts on murine dermal gammadelta-T cells to suppress IL-17 (show IL17A Proteins) synthesis via AdipoR1.
This study demonstrated the presence of adiponectin and its receptors in the uteri, conceptuses, and trophoblasts of pregnant pigs and that the local adiponectin system is dependent on the stage of pregnancy.
Data suggest AdipoR1/adiponectin signaling up-regulates gene expression of hepatocyte enzymes involved in fatty acid metabolism and protects hepatocyte from nonesterified fatty acids by activating phosphatidylinositol 3-kinase (PI3K/AKT (show AKT1 Proteins)) signaling.
study demonstrated that adiponectin and adiponectin receptors 1 and 2 messenger RNAs and proteins are present in the porcine hypothalamus and that their expression levels are determined by the pig's endocrine status related to the oestrous cycle
This study demonstrated the presence of adiponectin, AdipoR1 and AdipoR2 genes and proteins in the porcine uterus and the effect of the stage of the oestrous cycle on the expression of the adiponectin system.
Data indicate that AdipoR1 and AdipoR2 mRNAs and proteins are present in the porcine pituitary and that adiponectin receptors expression is dependent on endocrine status of the animals.
Results showed a high polymorphism of the ADIPOR1 and a complexity in its transcription level in longissimus dorsi from five pig breeds: Duroc, Polish Large White, Polish Landrace, Pietrain and Pulawska.
The cloning and characterization of adiponectin, ADIPOR1, and ADIPOR2 (show ADIPOR2 Proteins) are reported.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (show DGAT1 Proteins) (SSC4p15), PPARA (show PPARA Proteins) (SSC5p15), ADIPOR1 (SSC10p13) and CREB (show CREB1 Proteins) (SSC15q24)
Insulin regulates the expression of adiponectin and adiponectin receptors in porcine adipocytes.
Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 and AdipoR2 (show ADIPOR2 Proteins) mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern.
The physiologic status of the ovary has significant effects on the natural expression patterns of adiponectin and its receptors in follicular and luteal cells of bovine ovary.
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14.
adiponectin receptor 1
, adiponectin receptor type I
, adiponectin receptor protein 1
, progestin and adipoQ receptor family member I
, adiponectin receptor protein 1-like