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Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2 (show NRBF2 Proteins)), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 (show NRBF2 Proteins) is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.
This study reveals NRBF2 (show NRBF2 Proteins) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
Atg38 and its human ortholog NRBF2 (show NRBF2 Proteins), accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6 (show BECN1 Proteins)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1 (show BECN1 Proteins)-ATG14 (human), were characterized.
p300 (show EP300 Proteins)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Low VPS34 expression is associated with cancer.
Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway.
Vps34 has a previously unknown role in regulating Rab7 (show RAB7B Proteins) activity and late endosomal trafficking.
High expression of VPS34 promoted GRP78 (show HSPA5 Proteins) transcription by modulating ATF6 (show ATF6 Proteins). VPS34 could enhance GRP78 (show HSPA5 Proteins) protein stability.
These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs
This study uncovers a dual role for Vps34 as a regulator of platelet production by megakaryocytes and as an unexpected regulator of platelet activation and arterial thrombus formation dynamics.
E. chaffeensis secretes Etf-1 (show ETF1 Proteins) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 (show RAB5A Proteins) and class III PtdIns3K, while avoiding autolysosomal killing.
p300 (show NOTCH1 Proteins)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Vps34 has a previously unknown role in regulating Rab7 (show RAB7A Proteins) activity and late endosomal trafficking.
PIK3C3 was strongly expressed in the axon of cortical neurons during brain development.
provide the novel evidence that GADD45A (show GADD45A Proteins) inhibits autophagy via impairing the BECN1 (show BECN1 Proteins)-PIK3C3 complex formation
PAQR3 (show PAQR3 Proteins) controls autophagy by integrating AMPK (show PRKAA1 Proteins) signaling to enhance ATG14L-associated PI3K activity
Depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin (show INS Proteins) sensitivity and Akt (show AKT1 Proteins) signaling.
Study identifies a key role of Cul3 (show CUL3 Proteins)-KLHL20 (show KLHL20 Proteins) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Proteins) and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis (By similarity).
phosphoinositide-3-kinase, class 3
, phosphatidylinositol 3-kinase catalytic subunit type 3
, PI3K type 3
, PI3-kinase type 3
, ptdIns-3-kinase type 3
, phosphoinositide-3-kinase class 3
, catalytic phosphatidylinositol 3-kinase 3
, PtdIns-3-kinase type 3
, phosphatidylinositol 3-kinase p100 subunit
, class 3 phosphoinositide-3-kinase
, PI-3K Vps34p