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anti-Human PRKAA1 Antibodies:
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Cow (Bovine) Polyclonal PRKAA1 Primary Antibody for ICC, IF - ABIN151706
Zang, Zuccollo, Hou, Nagata, Walsh, Herscovitz, Brecher, Ruderman, Cohen: AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. in The Journal of biological chemistry 2004
Show all 12 Pubmed References
Human Monoclonal PRKAA1 Primary Antibody for ELISA, FACS - ABIN4280435
Xiao, Kwong, Daemen, Belvin, Liang, Hatzivassiliou, OBrien: Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable. in PLoS ONE 2016
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Human Polyclonal PRKAA1 Primary Antibody for IF (p), IHC (p) - ABIN737886
Fu, Zhu, Dodson, Du: AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. in The Journal of biological chemistry 2015
Show all 4 Pubmed References
Human Polyclonal PRKAA1 Primary Antibody for IHC, WB - ABIN6672695
Zheng, Zhou, Zhang, Thu, Xie, Lu, Pang, Xue, Xu, Chen, Chen, Li, Xu: Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. in Biochemical pharmacology 2017
Show all 3 Pubmed References
Mouse (Murine) Polyclonal PRKAA1 Primary Antibody for IHC, WB - ABIN3021788
Xiong, Zhang, Zhao, Zhao, Chen, Mei: Antidiabetic activities of entagenic acid in type 2 diabetic db/db mice and L6 myotubes via AMPK/GLUT4 pathway. in Journal of ethnopharmacology 2018
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Human PRKAA1 Primary Antibody for IHC - ABIN965547
Hurley, Anderson, Franzone, Kemp, Means, Witters: The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. in The Journal of biological chemistry 2005
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Human Polyclonal PRKAA1 Primary Antibody for IHC - ABIN965548
Woods, Johnstone, Dickerson, Leiper, Fryer, Neumann, Schlattner, Wallimann, Carlson, Carling: LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. in Current biology : CB 2003
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Human Polyclonal PRKAA1 Primary Antibody for ELISA, WB - ABIN5693057
Hou, Zheng, Li, Gao, Zhang: The protective effect of glycyrrhizic acid on renal tubular epithelial cell injury induced by high glucose. in International journal of molecular sciences 2015
Show all 2 Pubmed References
Human Monoclonal PRKAA1 Primary Antibody for ICC, FACS - ABIN969364
Pan, Yang, Cao, Song, Wallin, Kivlin, Lu, Hu, Di, Wan: AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. in Oncology reports 2008
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Human Polyclonal PRKAA1 Primary Antibody for IF, IHC - ABIN6675847
Yan, Du, Li, Chen, Yan, Chen, Hu, Chang: CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo. in Urologic oncology 2018
Moderate-intensity aerobic exercise training program improved insulin sensitivity in Systemic lupus erythematosus patients with mild/inactive disease. This effect appears to be partially mediated by the increased insulin-stimulated skeletal muscle AMPK phosphorylation.
PRKAA1 rs13361707 genetic variant was not linked with the development of atrophic gastritis or gastric cancer.
AMPK activity in response to redox changes is not due to direct action on AMPK itself, but is a secondary consequence of redox effects on other processes, such as mitochondrial ATP production.
AMP-activated protein kinase can be modulated by diverse ligands and by phosphorylation.
A double-negative feedback loop between Akt and AMPK controls the switch between matrix-attached and matrix-detached states needed to coordinate cell growth and survival during breast cancer metastasis.
The PRKAA1 rs13361707 polymorphism was not associated with the increased risk of cancer, while the A allele of PRKAA1 rs10074991 revealed a significantly decreased risk.
Our modeling results demonstrate a direct association between the activities of AMPK and HIF-1, master regulators of OXPHOS and glycolysis, respectively, with the activities of three major metabolic pathways: glucose oxidation, glycolysis, and fatty acid oxidation.
type I PKA regulatory subunits (RIalpha) interact with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-REX1), a chemotactic Rac guanine exchange factor (RacGEF). RIalpha CNB-B domain is critical for the interaction with P-REX1, which was increased in RIalpha mutants, such as the acrodysostosis-associated mutant, that activate P-REX1 at basal cAMP levels.
Data showed that rheumatoid arthritis (RA) T cells had a defect in type I N-myristoyltransferase (NMT1) function, which prevented AMP-activated protein kinase (AMPK) activation.
AMPK is an essential regulator for Akt activation by various stresses.
AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase
endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of protein kinase AMP-activated (PRKA)/AMP-activated protein kinases (AMPKs).
Genistein-mediated AMPK activation increases hepatocyte apoptosis through energy-dependent caspase pathways, suppresses the inflammatory response in resident liver macrophages by increased cellular respiration, and consequently inhibits the initiation and progression of hepatocellular carcinoma .
these data strongly suggested that AMPK activation may be enhanced in HCT116 p53/ cells under serumdepleted conditions via a drop in cellular ATP levels. In addition, activated AMPK may be at least partially responsible for the inhibition of necroptosis in HCT116 p53/ cells, but not in HCT116 p53+/+cells.
The results show that AMPK activation by GSK773 evokes the slow, oxidative myogenic program and triggers beneficial phenotypic adaptations in FAO-deficient myotubes. Thus, GSK773 might have therapeutic potential for correction of CPT2 deficiency
Collectively, our findings demonstrate the therapeutic potential of chronic AMPK stimulation both physiologically and pharmacologically for Myotonic dystrophy type 1 patients
This suggests that the failure of electrical pulse stimulation to activate AMPK in these muscle cultures is due to a defect proximal to AMPK. Further work is required to delineate the defect and determine whether pharmacological activation of AMPK improves muscle function in patients with myalgic encephalomyelitis (ME)/chronic fatigue syndrome .
High AMPK expression is associated with drug resistance in triple-negative breast cancer.
This review discusses recent advancements in the understanding of molecular, cellular, and physiological processes impacted by AMPK-glycogen interactions. These multidisciplinary research advances will aid the discovery of novel pathways and regulatory mechanisms that are central to the AMPK signaling network, beneficial effects of exercise and maintenance of metabolic homeostasis in health and disease. [review]
cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) activation is required for IL-24-induced cell death in a variety of breast cancer cell lines.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha-RUNX2 pathway.
AMPK-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR-1285 and thus activating AMP-activated protein kinase (AMPK).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I-stimulated PI3K pathway activation through stimulation of IRS-1 serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
endothelial expressed alpha1AMPK limits the recruitment of inflammatory cells to the vessel wall and maintains HO-1 mediated antioxidant defense
Study in Ampkalpha1-knockout and wild-type mice revealed that knockout mice had a higher serum Fgf23 concentration compared to wild-type mice. AMPK activator down-regulated, whereas the AMPK inhibitor induced Fgf23 transcription. Thus, AMPK participates in the regulation of Fgf23.
METRNL alleviates inflammation and insulin resistance and induces fatty acid oxidation through AMPK or PPARdelta-dependent signaling in skeletal muscle.
High fat diet-caused renal injury involved the inactivation of Pax2 and Ampk, and the activation of soluble epoxide hydrolase (sEH), in a murine model.
Metabolic regulation of female puberty is accomplished via hypothalamic AMPK-Kiss1 signaling.
Collectively, our findings demonstrate the therapeutic potential of chronic AMPK stimulation both physiologically and pharmacologically for Myotonic dystrophy type 1 patients.
AMP-activated protein kinase controls immediate early genes expression following synaptic activation through the PKA/CREB pathway.
our study demonstrates for the first time that fraxinellone has the effect on senescence inhibition and AMPK activation, and supports the notion that autophagic mechanism is important for aging prevention. These findings expanded the list of natural compounds and will be potentially utilized for aging decay and/or AMPK activation
These findings indicate that AMPK promotes the assembly of beta1Pix, 14-3-3 proteins, and Nedd4-2 into a complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and its degradation.
FSH enhances CRTC2-mediated gluconeogenesis dependent on AMPK Ser485 phosphorylation via GRK2 in the liver, suggesting an essential role of FSH in the pathogenesis of fasting hyperglycaemia
data also suggest that metformin affords beneficial effects, at least in part, independently of AMPKalpha1 and secondary to AMPKalpha2 activation, increase of Complex II function and reduction of oxidative stress.
hepatic Ago2-mediated RNA silencing has a role in regulating energy metabolism linked to AMPK activation and obesity-associated pathophysiology
AMPK may be a critical regulator of fibroblast activation through regulation of cytoskeleton dynamics and myocardin-related transcription factor-A nuclear translocation, promoting renal fibrosis.
these findings identify a previously uncharacterized role of folate/DHFR/AMPKalpha axis in regulating oligodendrocyte survival and myelination.
CNR1 modulates AMPKalpha to influence insulin resistance and endoplasmic reticulum stress induced by palmitate.
Inhibiting the LTB4/BLT1 signaling pathway via AMPK activation is a potential treatment strategy for septic cardiac dysfunction because it efficiently attenuates cardiac apoptosis, which may occur via the inhibition of inflammation and mitochondrial dysfunction.
Thus, these findings suggest that AMPKalpha1 and AMPKalpha2 activity in chondrocytes is important in maintaining joint homeostasis and osteoarthritis development.
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A exists in a functional cellular complex with AMPK and CFTR in airway epithelia, and NDPK-A catalytic function is required for the AMPK-dependent regulation of CFTR
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit