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anti-Human PRKAA1 Antibodies:
anti-Rat (Rattus) PRKAA1 Antibodies:
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Cow (Bovine) Polyclonal PRKAA1 Primary Antibody for ICC, IF - ABIN151706
Zang, Zuccollo, Hou, Nagata, Walsh, Herscovitz, Brecher, Ruderman, Cohen: AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. in The Journal of biological chemistry 2004
Show all 12 Pubmed References
Human Polyclonal PRKAA1 Primary Antibody for IF (p), IHC (p) - ABIN737886
Fu, Zhu, Dodson, Du: AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. in The Journal of biological chemistry 2015
Show all 7 Pubmed References
Human Monoclonal PRKAA1 Primary Antibody for ELISA, FACS - ABIN4280435
Xiao, Kwong, Daemen, Belvin, Liang, Hatzivassiliou, OBrien: Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable. in PLoS ONE 2016
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Mouse (Murine) Polyclonal PRKAA1 Primary Antibody for IHC, WB - ABIN3021788
Zheng, Zhou, Zhang, Thu, Xie, Lu, Pang, Xue, Xu, Chen, Chen, Li, Xu: Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. in Biochemical pharmacology 2017
Show all 3 Pubmed References
Human Polyclonal PRKAA1 Primary Antibody for IHC - ABIN965548
Hurley, Anderson, Franzone, Kemp, Means, Witters: The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. in The Journal of biological chemistry 2005
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Human PRKAA1 Primary Antibody for IHC - ABIN965547
Woods, Johnstone, Dickerson, Leiper, Fryer, Neumann, Schlattner, Wallimann, Carlson, Carling: LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. in Current biology : CB 2003
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Human Polyclonal PRKAA1 Primary Antibody for IHC, WB - ABIN6672695
Xiong, Zhang, Zhao, Zhao, Chen, Mei: Antidiabetic activities of entagenic acid in type 2 diabetic db/db mice and L6 myotubes via AMPK/GLUT4 pathway. in Journal of ethnopharmacology 2018
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Human Polyclonal PRKAA1 Primary Antibody for ELISA, WB - ABIN5693057
Hou, Zheng, Li, Gao, Zhang: The protective effect of glycyrrhizic acid on renal tubular epithelial cell injury induced by high glucose. in International journal of molecular sciences 2015
Show all 2 Pubmed References
Human Monoclonal PRKAA1 Primary Antibody for ICC, FACS - ABIN969364
Pan, Yang, Cao, Song, Wallin, Kivlin, Lu, Hu, Di, Wan: AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. in Oncology reports 2008
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Human Polyclonal PRKAA1 Primary Antibody for IF, IHC - ABIN6675847
Yan, Du, Li, Chen, Yan, Chen, Hu, Chang: CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo. in Urologic oncology 2018
CHK1 contains a beta-TrCP recognizable degron domain, which is phosphorylated by AMPK in response to glucose deprivation.
MiR-937 could screen patients with metabolic disorders from healthy controls by targeting AMP-activated protein kinases (AMPKalpha).
an AMPK-LTBP4 axis in inflammatory macrophages controls the production of TGF-beta1, which is further activated by and acts on fibroblastic cells, leading to fibrosis in Duchenne muscular dystrophy.
Serum AMPK was higher in patients with severe-Pre-Eclampsia compared with healthy pregnant women and patients with Pre-Eclampsia without severe features so it might be a new biomarker for the prediction of disease and its severity.
Iron loading promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.
Our results indicated that metformin-AMPK-CEBPbeta signaling plays a crucial role in regulating the gene expression of CD133. Additionally, regulating the ratio of LAP/LIP may be a novel strategy for targeting cancer stem-like cells for the treatment of cancer.
Antidiabetic effect of the tested amino acids was exhibited by increased glucose uptake through the AMPK pathway by an APN-dependent mechanism in human visceral adipocytes. This should be tested and confirmed in in vivo system. Newer treatment modalities with amino acids which can enhance glucose uptake and APN secretion can be developed as drug for treating both diabetes and obesity.
We analysed AMPK phosphorylation, dopamine D2 receptor (D2R), and oestrogen receptor (ER) expression in both BC-sensitive and -resistant PRLoma samples; effects of the AMPK agonist MET (alone or with BC) on in vitro proliferation and apoptosis, xenograft growth and prolactin (PRL) secretion of BC-sensitive and -resistant cells, and ER expression in xenografts.
The authors show that AMPK alpha1 is required for efficient autophagosome maturation and lysosomal fusion.
Mechanistically, AMP-activated protein kinase (AMPK)-mediated phosphorylation of BECN1 at Ser90/93/96 is required for BECN1-SLC7A11 complex formation and lipid peroxidation.
The stretch-induced antioxidant effect was through activation of the AMPK-SIRT1 signaling pathway. Our findings demonstrated that appropriate mechanical stimulation can improve Mesenchymal stem cells (MSCs) antioxidant functions and benefit bone regeneration.
TRIM8 knockdown effectively protected lipopolysaccharide-induced acute liver failure against inflammation and oxidative stress largely dependent on the promotion of AMPKalpha pathway.
AMPK and eNOS inhibition/knockout decreased autophagic activity in the ischemic postconditioning (IPostC) group. These results indicated that IPostC protects the heart against I/R injury, partially via promoting AMPK/eNOS-mediated autophagy
Results of cell-based assays in which AICAR is used for AMPK activation therefore critically depend on media formulation. Furthermore, our findings highlight a role for extracellular nucleosides and nucleoside transporters in regulation of AMPK activation.
Moderate-intensity aerobic exercise training program improved insulin sensitivity in Systemic lupus erythematosus patients with mild/inactive disease. This effect appears to be partially mediated by the increased insulin-stimulated skeletal muscle AMPK phosphorylation.
PRKAA1 rs13361707 genetic variant was not linked with the development of atrophic gastritis or gastric cancer.
AMPK activity in response to redox changes is not due to direct action on AMPK itself, but is a secondary consequence of redox effects on other processes, such as mitochondrial ATP production.
AMP-activated protein kinase can be modulated by diverse ligands and by phosphorylation.
A double-negative feedback loop between Akt and AMPK controls the switch between matrix-attached and matrix-detached states needed to coordinate cell growth and survival during breast cancer metastasis.
The PRKAA1 rs13361707 polymorphism was not associated with the increased risk of cancer, while the A allele of PRKAA1 rs10074991 revealed a significantly decreased risk.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha-RUNX2 pathway.
AMPK-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR-1285 and thus activating AMP-activated protein kinase (AMPK).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I-stimulated PI3K pathway activation through stimulation of IRS-1 serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
alpha1AMPK deletion in myelomonocytic cells aggravates vascular oxidative stress and dysfunction by enhancing their recruitment to the vascular wall and increasing their susceptibility towards pro-oxidant stimuli.
The authors found that cingulin's binding properties to actin filaments and microtubules was regulated by AMPK-dependent phosphorylation that changed its conformation and binding properties.
AMPKalpha/AP-2alpha/miR-124/P4Halpha1 axis plays a crucial role in the regulation of collagen synthesis in advanced atherosclerotic lesions. Targeting AMPKalpha/AP-2alpha/miRNA-124/P4Halpha1 signaling should be considered to increase the plaque stability in patients with atherosclerosis.
Data suggest that serine threonine kinase 11 (LKB1) - 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK-alpha1) signaling pathways downstream of mitochondria are critical for the induction of hypoxic pulmonary vasoconstriction (HPV).
Our results suggest that irisin protects against pressure overload-induced cardiac hypertrophy by inducing protective autophagy and autophagy flux via activating AMPK-ULK1 signaling.
Our data implicated that metformin exerts its therapeutic effects on Multiple sclerosis (MS) by AMPK signaling improved mitochondrial homeostasis and protected oligodendrocytes.
AMPK-ACC signaling is coupled to the control of thrombosis by specifically modulating thromboxane and granule release in response to collagen.
endothelial expressed alpha1AMPK limits the recruitment of inflammatory cells to the vessel wall and maintains HO-1 mediated antioxidant defense
Study in Ampkalpha1-knockout and wild-type mice revealed that knockout mice had a higher serum Fgf23 concentration compared to wild-type mice. AMPK activator down-regulated, whereas the AMPK inhibitor induced Fgf23 transcription. Thus, AMPK participates in the regulation of Fgf23.
METRNL alleviates inflammation and insulin resistance and induces fatty acid oxidation through AMPK or PPARdelta-dependent signaling in skeletal muscle.
High fat diet-caused renal injury involved the inactivation of Pax2 and Ampk, and the activation of soluble epoxide hydrolase (sEH), in a murine model.
Metabolic regulation of female puberty is accomplished via hypothalamic AMPK-Kiss1 signaling.
AMPK is an essential regulator for Akt activation by various stresses.
endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of protein kinase AMP-activated (PRKA)/AMP-activated protein kinases (AMPKs).
Genistein-mediated AMPK activation increases hepatocyte apoptosis through energy-dependent caspase pathways, suppresses the inflammatory response in resident liver macrophages by increased cellular respiration, and consequently inhibits the initiation and progression of hepatocellular carcinoma .
Collectively, our findings demonstrate the therapeutic potential of chronic AMPK stimulation both physiologically and pharmacologically for Myotonic dystrophy type 1 patients.
AMP-activated protein kinase controls immediate early genes expression following synaptic activation through the PKA/CREB pathway.
our study demonstrates for the first time that fraxinellone has the effect on senescence inhibition and AMPK activation, and supports the notion that autophagic mechanism is important for aging prevention. These findings expanded the list of natural compounds and will be potentially utilized for aging decay and/or AMPK activation
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A exists in a functional cellular complex with AMPK and CFTR in airway epithelia, and NDPK-A catalytic function is required for the AMPK-dependent regulation of CFTR
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit