IL-33 antibody
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- Target See all IL-33 (IL33) Antibodies
- IL-33 (IL33) (Interleukin 33 (IL33))
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Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This IL-33 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Specificity
- Recognizes human and mouse IL-33.
- Cross-Reactivity
- Human, Mouse (Murine)
- Sterility
- 0.2 μm filtered
- Immunogen
- Recombinant human IL-33.
- Clone
- IL33026B
- Isotype
- IgG1
- Top Product
- Discover our top product IL33 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
- Preservative
- Without preservative
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - Expiry Date
- 12 months
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- Target
- IL-33 (IL33) (Interleukin 33 (IL33))
- Alternative Name
- IL-33 (IL33 Products)
- Background
- Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL33 is converted by CASP1 to a 18 kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
- UniProt
- O95760
- Pathways
- Production of Molecular Mediator of Immune Response
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