Granulin antibody (GRN)

Details for Product anti-GRN Antibody No. ABIN1169391
Antigen
  • GRN
  • grn
  • wu:fb11g12
  • wu:fj18f05
  • MGC53354
  • DKFZp459H066
  • CLN11
  • GEP
  • GP88
  • PCDGF
  • PEPI
  • PGRN
  • epithelin
  • acrogranin
  • granulin precursor
  • granulin a
  • Granulins
  • granulin L homeolog
  • granulin
  • GRN
  • grna
  • grn
  • grn.L
  • granulin
  • ORF1 granulin
  • Grn
Reactivity
Human
112
46
25
2
1
1
1
Host
Guinea Pig
85
25
12
10
4
Clonality
Polyclonal
Conjugate
This Granulin antibody is un-conjugated
10
7
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
99
61
45
15
14
13
10
10
8
4
2
Options
Immunogen Recombinant human progranulin.
Specificity Recognizes human progranulin. Detects a band of ~90 kDa by Western blot.
Cross-Reactivity Human
Cross-Reactivity (Details) Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.
Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others Granulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Progranulin (GRN Antibody Abstract)
Background Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
UniProt P28799
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Preservative Without preservative
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Expiry Date 6 months
Supplier Images
Image no. 1 for anti-Granulin (GRN) antibody (ABIN1169391) Western blot analysis using anti-Progranulin (human), pAb at 1:2'000 dilution. 1: Hu...
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