Granulin antibody

Catalog No. ABIN1169391

Product Details anti-Granulin Antibody

Target: Granulin (GRN)

Reactivity: Human

Host: Guinea Pig

Clonality: Polyclonal

Conjugate: This Granulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: Recognizes human progranulin. Detects a band of ~90 kDa by Western blot.

Cross-Reactivity: Human

Cross-Reactivity (Details): Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human progranulin.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for Granulin

Target: Granulin (GRN)

Alternative Name: Progranulin (GRN Products)

Target Type: Viral Protein

Background: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

UniProt: P28799