Granulin antibody (C-Term)

Catalog No. ABIN1881391

This Rabbit Polyclonal antibody specifically detects Granulin in WB and IHC (p). It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for Granulin antibody (C-Term) (ABIN1881391)

Target: Granulin (GRN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Granulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB44397

Product Details anti-Granulin Antibody

Binding Specificity: AA 563-591, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-591 amino acids from the C-terminal region of human GRN.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Granulin antibody (ABIN1881391)

Bhandari, Bateman: "Structure and chromosomal location of the human granulin gene." in: Biochemical and biophysical research communications, Vol. 188, Issue 1, pp. 57-63, (1992) (PubMed).

Plowman, Green, Neubauer, Buckley, McDonald, Todaro, Shoyab: "The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth." in: The Journal of biological chemistry, Vol. 267, Issue 18, pp. 13073-8, (1992) (PubMed).

Bhandari, Palfree, Bateman: "Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 5, pp. 1715-9, (1992) (PubMed).

Target Details for Granulin

Target: Granulin (GRN)

Alternative Name: GRN

Background: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

Molecular Weight: 63544

NCBI Accession: NP_002078

UniProt: P28799