FNDC5 antibody (Biotin)

Catalog No. ABIN1169431

Product Details anti-FNDC5 Antibody (Biotin)

Target: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNDC5 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Specificity: Recognizes human, mouse, rat, monkey Irisin and FNDC5. Detects endogenous mouse and human Irisin [Lit: 1-2].

Cross-Reactivity: Human, Monkey, Mouse (Murine), Rat (Rattus)

Immunogen: Recombinant irisin.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for FNDC5

Target: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Alternative Name: Irisin (FNDC5 Products)

Background: Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

UniProt: Q8NAU1

Pathways: Hormone Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation