Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ROBO1 antibody (Roundabout, Axon Guidance Receptor, Homolog 1) (AA 1632-1644) Primary Antibody

ROBO1 Reactivity: Human IP, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Pubmed (1)
Catalog No. ABIN129621
$628.50
Plus shipping costs $45.00 and $24.00 dry ice
100 μg ABIN129621
100 μg ABIN129621
local_shipping Shipping to: United States
Delivery in 1 to 2 Business Days
  • Target
    ROBO1
    Binding Specificity
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1632-1644
    Reactivity
    • 32
    • 14
    • 13
    • 2
    • 1
    Human
    Host
    • 21
    • 8
    • 6
    Rabbit
    Clonality
    • 30
    • 5
    Polyclonal
    Conjugate
    • 19
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ROBO1 antibody is un-conjugated
    Application
    • 26
    • 23
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Dog (Canine)
    Characteristics
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1632-1644 of Human ROBO-1.
    Isotype
    IgG
  • Application Notes
    This affinity purified antibody has been tested for use in ELISA , IP, immunohistochemistry, immunofluorescence, and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~181 kDa in size corresponding to ROBO-1 by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Li, Wang, Chen, Liang: "[Auditory neuropathy in children(analysis of 14 cases)]." in: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, Vol. 19, Issue 1, pp. 19-21, 2006 (PubMed).

  • Target
    ROBO1
    Alternative Name
    ROBO-1 (ROBO1 Antibody Abstract)
    Synonyms
    DUTT1, SAX3, AW494633, AW742721, Gm310, ROBO1, dutt1, roundabout, sax3, MGC122264, roundabout-1, roundabout guidance receptor 1, roundabout, axon guidance receptor, homolog 1 (Drosophila), roundabout guidance receptor 1 L homeolog, ROBO1, Robo1, robo1, robo1.L
    Background
    ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2.  The SLIT proteins are thought to act as a molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex.  ROBO-1 may also be required for lung development. ROBO-1 is a type I membrane protein.  ROBO-1 is a widely expressed protein with the exception of the kidney.  Defects in ROBO1 may be a cause of breast and lung cancer. ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. Multiple splice variants have been identified for this protein.
    Synonyms: ROBO-1, Roundabout homolog 1 precursor, Deleted in U twenty twenty (DUTT)
    Gene ID
    6091
    UniProt
    Q2M1J3
    Pathways
    Positive Regulation of Endopeptidase Activity
You are here:
help Support