ROBO1 antibody (AA 29-143)

Catalog No. ABIN7168440

The Rabbit Polyclonal anti-ROBO1 antibody is suitable to detect ROBO1 in samples from Human. It has been validated for WB, ELISA and IF.

Quick Overview for ROBO1 antibody (AA 29-143) (ABIN7168440)

Target: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ROBO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-ROBO1 Antibody

Binding Specificity: AA 29-143

Purpose: ROBO1 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Roundabout homolog 1 protein (29-143AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ROBO1

Target: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Alternative Name: ROBO1

Background:

Background: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B, inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).

Aliases: Deleted in U twenty twenty antibody, DUTT 1 antibody, DUTT1 antibody, FLJ21882 antibody, H Robo 1 antibody, H-Robo-1 antibody, hRobo 1 antibody, Robo 1 antibody, Robo1 antibody, ROBO1_HUMAN antibody, Roundabout 1 antibody, Roundabout axon guidance receptor homolog 1 antibody, Roundabout homolog 1 antibody, Roundabout homolog1 precurser antibody, Roundabout1 antibody, SAX 3 antibody, SAX3 antibody

UniProt: Q9Y6N7

Pathways: Positive Regulation of Endopeptidase Activity