Macrophage Mannose Receptor 1 antibody (AA 201-300)

Catalog No. ABIN1386219

Product Details anti-Macrophage Mannose Receptor 1 Antibody

Target: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Binding Specificity: AA 201-300

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Macrophage Mannose Receptor 1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Dog, Human, Mouse, Rat

Predicted Reactivity: Cow,Sheep,Pig,Horse,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MRC1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Macrophage Mannose Receptor 1 antibody (ABIN1386219)

Locatelli, Cadamuro, Spirlì, Fiorotto, Lecchi, Morell, Popov, Scirpo, De Matteis, Amenduni, Pietrobattista, Torre, Schuppan, Fabris, Strazzabosco: "Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis." in: Hepatology (Baltimore, Md.), Vol. 63, Issue 3, pp. 965-82, (2016) (PubMed).

Zhu, Yang, Liu, Zheng, Ji, Zuo: "M2 Macrophage Transplantation Ameliorates Cognitive Dysfunction in Amyloid-β-Treated Rats Through Regulation of Microglial Polarization." in: Journal of Alzheimer's disease : JAD, Vol. 52, Issue 2, pp. 483-95, (2016) (PubMed).

Struecker, Hillebrandt, Raschzok, Jöhrens, Butter, Tang, Andreou, Napierala, Reutzel-Selke, Denecke, Pratschke, Sauer: "Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs." in: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes, Vol. 56, Issue 1-2, pp. 61-75, (2016) (PubMed).

Blomgran, Blomgran, Ernerudh, Aspenberg: "A possible link between loading, inflammation and healing: Immune cell populations during tendon healing in the rat." in: Scientific reports, Vol. 6, pp. 29824, (2016) (PubMed).

Das, Segar, Chu, Wang, Lin, Yang, Du, Ogle, Cui, Botchwey: "Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras." in: Biomaterials, Vol. 64, pp. 98-107, (2015) (PubMed).

Azad, Rajaram, Metz, Cope, Blue, Vera, Schlesinger: "?-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)." in: Journal of immunology (Baltimore, Md. : 1950), (2015) (PubMed).

Sendler, Beyer, Mahajan, Kauschke, Maertin, Schurmann, Homuth, Völker, Völzke, Halangk, Wartmann, Weiss, Hegyi, Lerch, Mayerle: "Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis." in: Gastroenterology, Vol. 149, Issue 3, pp. 765-76.e10, (2015) (PubMed).

Ding, Wang, Wang, Yang, Xue: "Expression of Tumor-Associated Macrophage in Progression of Human Glioma." in: Cell biochemistry and biophysics, (2014) (PubMed).

Karmouty-Quintana, Philip, Acero, Chen, Weng, Molina, Luo, Davies, Le, Bunge, Volcik, Le, Johnston, Xia, Eltzschig, Blackburn: "Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, (2014) (PubMed).

Target Details for Macrophage Mannose Receptor 1

Target: Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))

Alternative Name: MRC1 (MRC1 Products)

Background:

Synonyms: MMR, CD206, MRC1L1, CLEC13D, CLEC13DL, bA541I19.1, Macrophage mannose receptor 1, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Macrophage mannose receptor 1-like protein 1, MRC1

Background: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Gene ID: 4360

UniProt: P22897