ARNTL2 antibody (AA 381-480) (Biotin)

Catalog No. ABIN1391323

Product Details anti-ARNTL2 Antibody (Biotin)

Target: ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2))

Binding Specificity: AA 381-480

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARNTL2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARNTL2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ARNTL2

Target: ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2))

Alternative Name: ARNTL2/BMAL2 (ARNTL2 Products)

Background:

Synonyms: ARNT L2, ARNTL 2, ARNTL2, ARNTL2 protein, Aryl hydrocarbon receptor nuclear translocator like 2, Aryl hydrocarbon receptor nuclear translocator like protein 2, Aryl hydrocarbon receptor nuclear translocator-like 2, Basic helix loop helix PAS protein MOP9, Basic-helix-loop-helix-PAS protein MOP9, bHLHe6, BMA L2, BMAL 2, BMAL2, Brain and muscle ARNT like 2, Brain and muscle ARNT-like 2, CL, CYCLE like factor, CYCLE-like factor, Member of PAS protein 9, MGC124257, MGC149671, MGC149672, MGC158186, MOP 9, MOP9, PASD 9, PASD9, Transcription factor BMAL 2, Transcription factor BMAL2, wu:fj90c09, BMAL2_HUMAN.

Background: BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.

Gene ID: 56938

Pathways: Photoperiodism