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SIM2 antibody (Single-Minded Homolog 2) AA 321-430 (FITC) Primary Antibody

SIM2 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal FITC
Catalog No. ABIN1394282
$476.30
Plus shipping costs $45.00
100 μL
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  • Target See all SIM2 Antibodies
    SIM2
    Binding Specificity
    • 14
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 321-430
    Reactivity
    • 28
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    • 7
    • 3
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 13
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIM2 antibody is conjugated to FITC
    Application
    • 19
    • 17
    • 12
    • 12
    • 4
    • 3
    • 2
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SIM2
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    SIM2
    Alternative Name
    SIM2 (SIM2 Products)
    Synonyms
    Xsim2, sim2-A, xSim, HMC13F06, HMC29C01, SIM, bHLHe15, single-minded family bHLH transcription factor 2 S homeolog, single-minded family bHLH transcription factor 2, single-minded homolog 2 (Drosophila), sim2.S, sim2, SIM2, Sim2
    Background

    The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors. Several PAS domain family members have been identified including AhR, Arnt 1, and single-minded proteins (SIM1 and SIM2). The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand- dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element. Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, thus inhibiting transcriptional activation. The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, which is located on chromosome 21, is a candidate for the gene responsible for Down syndrome.

    Subcellular location: Nucleus

    Synonyms: bHLHe15, Class E basic helix loop helix protein 15, Class E basic helix-loop-helix protein 15, MGC119447, SIM 2, SIM, Sim2, SIM2_HUMAN, Single minded homolog 2 Drosophila, Single minded homolog 2, Single-minded homolog 2, Transcription factor SIM2.

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