M-CSF/CSF1 antibody (Colony Stimulating Factor 1 (Macrophage)) AA 201-300 (Alexa Fluor 488)

Catalog No. ABIN1397013

Product Details anti-M-CSF/CSF1 Antibody

Target: M-CSF/CSF1 (CSF1)

Binding Specificity: AA 201-300

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This M-CSF/CSF1 antibody is conjugated to Alexa Fluor 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MCSF

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details for M-CSF/CSF1

Target: M-CSF/CSF1 (CSF1)

Alternative Name: MCSF (CSF1 Products)

Synonyms: CSF-1, MCSF, C87615, Csfm, op, csf1-1, zgc:172186, CSF1, colony stimulating factor 1, colony stimulating factor 1 (macrophage), colony stimulating factor 1a (macrophage), macrophage colony-stimulating factor 1, macrophage colony stimulating factor, CSF1, Csf1, csf1a, LOC396599, LOC100860895

Background:

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Subcellular location: Secreted, Cell membrane, Extracellular matrix

Synonyms: MCSF, CSF-1, Macrophage colony-stimulating factor 1, M-CSF, Lanimostim, CSF1

Gene ID:

UniProt: P09603

Pathways: RTK Signaling