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Transglutaminase 2 antibody (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase)) AA 351-450 (FITC) Primary Antibody

TGM2 Reactivity: Human, Mouse IF (cc), IF (p) Host: Rabbit Polyclonal FITC
Catalog No. ABIN1399904
$476.30
Plus shipping costs $45.00
100 μL
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  • Target See all Transglutaminase 2 (TGM2) Antibodies
    Transglutaminase 2 (TGM2)
    Binding Specificity
    • 15
    • 13
    • 9
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 351-450
    Reactivity
    • 117
    • 57
    • 49
    • 22
    • 18
    • 11
    • 7
    • 4
    • 4
    • 3
    • 1
    Human, Mouse
    Host
    • 86
    • 38
    • 9
    • 1
    Rabbit
    Clonality
    • 90
    • 44
    Polyclonal
    Conjugate
    • 60
    • 14
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Transglutaminase 2 antibody is conjugated to FITC
    Application
    • 77
    • 38
    • 31
    • 25
    • 24
    • 24
    • 20
    • 19
    • 14
    • 11
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Transglutaminase 2
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    Transglutaminase 2 (TGM2)
    Alternative Name
    Transglutaminase 2 (TGM2 Products)
    Synonyms
    G-ALPHA-h, GNAH, TG2, TGC, tgm2, zgc:101081, TgaseII, TGM2, fc12b04, wu:fc12b04, zgc:136700, TGL2, G[a]h, TGase2, tTG, tTGas, transglutaminase 2, transglutaminase 2, C polypeptide A, transglutaminase 2b, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), transglutaminase 2, C polypeptide, TGM2, tgm2a, Tgm2, tgm2b
    Background

    Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.

    Subcellular location: Cytoplasm, Secreted, Cell membrane

    Synonyms: TG 2, TGC, TG2, TGase C, TGase H, TGase-2, TGase2, TgaseII, ALPHA SUBUNIT, C polypeptide, G alpha h, G protein alpha subunit Gh class, G[a]h, Gh CLASS G ALPHA h, GNAH, GNAH G PROTEIN, Guanine nucleotide binding protein H polypeptide, H POLYPEPTIDE, Protein glutamine gamma glutamyltransferase 2, Protein glutamine gamma glutamyltransferase, Protein-glutamine gamma-glutamyltransferase 2, TGC, TGC GUANINE NUCLEOTIDE BINDING PROTEIN, TGM 2, TGM2, TGM2_HUMAN, Tissue transglutaminase, Tissue type transglutaminase, Transglutaminase 2, Transglutaminase 2 C polypeptide, Transglutaminase C, Transglutaminase H, Transglutaminase-2, tTG, tTGas.

    Pathways
    Tube Formation, Thromboxane A2 Receptor Signaling
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