Transglutaminase 2 antibody (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase)) AA 351-450 (FITC) Primary Antibody
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- Target See all Transglutaminase 2 (TGM2) Antibodies
- Transglutaminase 2 (TGM2)
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Binding Specificity
- AA 351-450
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Transglutaminase 2 antibody is conjugated to FITC
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Transglutaminase 2
- Isotype
- IgG
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C/-80 °C
- Storage Comment
- Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
- Expiry Date
- 12 months
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- Target
- Transglutaminase 2 (TGM2)
- Alternative Name
- Transglutaminase 2 (TGM2 Products)
- Synonyms
- G-ALPHA-h, GNAH, TG2, TGC, tgm2, zgc:101081, TgaseII, TGM2, fc12b04, wu:fc12b04, zgc:136700, TGL2, G[a]h, TGase2, tTG, tTGas, transglutaminase 2, transglutaminase 2, C polypeptide A, transglutaminase 2b, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), transglutaminase 2, C polypeptide, TGM2, tgm2a, Tgm2, tgm2b
- Background
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Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.
Subcellular location: Cytoplasm, Secreted, Cell membrane
Synonyms: TG 2, TGC, TG2, TGase C, TGase H, TGase-2, TGase2, TgaseII, ALPHA SUBUNIT, C polypeptide, G alpha h, G protein alpha subunit Gh class, G[a]h, Gh CLASS G ALPHA h, GNAH, GNAH G PROTEIN, Guanine nucleotide binding protein H polypeptide, H POLYPEPTIDE, Protein glutamine gamma glutamyltransferase 2, Protein glutamine gamma glutamyltransferase, Protein-glutamine gamma-glutamyltransferase 2, TGC, TGC GUANINE NUCLEOTIDE BINDING PROTEIN, TGM 2, TGM2, TGM2_HUMAN, Tissue transglutaminase, Tissue type transglutaminase, Transglutaminase 2, Transglutaminase 2 C polypeptide, Transglutaminase C, Transglutaminase H, Transglutaminase-2, tTG, tTGas.
- Pathways
- Tube Formation, Thromboxane A2 Receptor Signaling