CYP11B2 antibody (AA 234-503)

Catalog No. ABIN1679468

Product Details anti-CYP11B2 Antibody

Target: CYP11B2 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2))

Binding Specificity: AA 234-503

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP11B2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: TVQLMFMPRS LSRWISPKVW KEHFEAWDCI FQYGDNCIQK IYQELAFNRP QHYTGIVAEL LLKAELSLEA IKANSMELTA GSVDTTAFPL LMTLFELARN PDVQQILRQE SLAAAASISE HPQKATTELP LLRAALKETL RLYPVGLFLE RVVSSDLVLQ NYHIPAGTLV QVFLYSLGRN AALFPRPERY NPQRWLDIRG SGRNFHHVPF GFGMRQCLGR RLAEAEMLLL LHHVLKHFLV ETLTQEDIKM VYSFILRPGT SPLLTFRAIN

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human CYP11B2 (NP_000489.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP11B2

Target: CYP11B2 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2))

Alternative Name: CYP11B2 (CYP11B2 Products)

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.,CYP11B2,ALDOS,CPN2,CYP11B,CYP11BL,CYPXIB2,P-450C18,P450C18,P450aldo,CYP11B2

Molecular Weight: 57 kDa

Gene ID: 1585

UniProt: P19099

Pathways: ACE Inhibitor Pathway, Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, C21-Steroid Hormone Metabolic Process, Feeding Behaviour