SLC7A5 antibody (AA 1-125)

Catalog No. ABIN1682793

Product Details anti-SLC7A5 Antibody

Target: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Binding Specificity: AA 1-125

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC7A5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV GTIIGSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM LEVYG

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human SLC7A5 (NP_003477.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SLC7A5 antibody (ABIN1682793)

Hu, Nie, Chen, Xie, Fan, Wang, Long, Yan, Zhong, Yan: "Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells." in: The international journal of biochemistry & cell biology, Vol. 89, pp. 42-56, (2017) (PubMed).

Target Details for SLC7A5

Target: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Alternative Name: SLC7A5 (SLC7A5 Products)

Background: The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity. May act as the major transporter of tyrosine in fibroblasts (Probable. May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity. Can mediate the transport of thyroid hormones triiodothyronine (T3 and thyroxine (T4 across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO across the membrane.,SLC7A5,4F2LC,CD98,D16S469E,E16,LAT1,MPE16,hLAT1,Cancer,Signal Transduction,Endocrine & Metabolism,SLC7A5

Molecular Weight: 55 kDa

Gene ID: 8140

UniProt: Q01650