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Allergin-1 antibody (AA 61-160) (AbBy Fluor® 350)

MILR1 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 350
Catalog No. ABIN1692930
  • Target See all Allergin-1 (MILR1) Antibodies
    Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))
    Binding Specificity
    • 14
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 61-160
    Reactivity
    • 25
    • 1
    Human
    Host
    • 22
    • 2
    • 1
    Rabbit
    Clonality
    • 23
    • 2
    Polyclonal
    Conjugate
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Allergin-1 antibody is conjugated to AbBy Fluor® 350
    Application
    • 12
    • 12
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Allergin-1
    Isotype
    IgG
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  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))
    Alternative Name
    Allergin-1 (MILR1 Products)
    Synonyms
    Allergin-1 antibody, Gm885 antibody, Mca32 antibody, C17orf60 antibody, MCA-32 antibody, MCA32 antibody, mast cell immunoglobulin like receptor 1 antibody, mast cell immunoglobulin-like receptor 1 antibody, Milr1 antibody, MILR1 antibody
    Background

    Synonyms: C17orf60,Chromosome 17 open reading frame 60.

    Background: As a major event in type allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcRIs on mast cells may inhibit the signal transduction from FcRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.

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