Allergin-1 antibody (AA 61-160) (AbBy Fluor® 647)
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- Target See all Allergin-1 (MILR1) Antibodies
- Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))
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Binding Specificity
- AA 61-160
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Allergin-1 antibody is conjugated to AbBy Fluor® 647
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Allergin-1
- Isotype
- IgG
- Top Product
- Discover our top product MILR1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))
- Alternative Name
- Allergin-1 (MILR1 Products)
- Synonyms
- Allergin-1 antibody, Gm885 antibody, Mca32 antibody, C17orf60 antibody, MCA-32 antibody, MCA32 antibody, mast cell immunoglobulin like receptor 1 antibody, mast cell immunoglobulin-like receptor 1 antibody, Milr1 antibody, MILR1 antibody
- Background
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Synonyms: C17orf60,Chromosome 17 open reading frame 60.
Background: As a major event in type allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcRIs on mast cells may inhibit the signal transduction from FcRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.
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