LAMTOR2 antibody (AA 3-100) (HRP)

Catalog No. ABIN1712086

Product Details anti-LAMTOR2 Antibody (HRP)

Target: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Binding Specificity: AA 3-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMTOR2 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ROBLD3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LAMTOR2

Target: LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))

Alternative Name: ROBLD3 (LAMTOR2 Products)

Synonyms: ENDAP antibody, HSPC003 antibody, MAPBPIP antibody, MAPKSP1AP antibody, ROBLD3 antibody, Ragulator2 antibody, p14 antibody, 2010111E04Rik antibody, AL022628 antibody, Mapbpip antibody, P14 antibody, Rab25 antibody, Robld3 antibody, RGD1562501 antibody, cg5189 antibody, endap antibody, hspc003 antibody, mapbpip antibody, mapbpip-B antibody, mapksp1ap antibody, ragulator2 antibody, robld3 antibody, robld3-b antibody, zgc:100811 antibody, lamtor2 antibody, lamtor2-a antibody, lamtor2-b antibody, mapbpip-A antibody, robld3-a antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog antibody, LAMTOR2 antibody, Lamtor2 antibody, lamtor2.S antibody, lamtor2 antibody, lamtor2.L antibody

Background:

Synonyms: ENDAP, Endosomal adaptor protein p14, HSPC003, LAMTOR2, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Late endosomal/lysosomal Mp1 interacting protein, Late endosomal/lysosomal Mp1-interacting protein, LTOR2_HUMAN, MAPBPIP, MAPKSP1 adaptor protein, MAPKSP1AP, Mitogen activated protein binding protein interacting protein, Mitogen-activated protein-binding protein-interacting protein, p14, Ragulator complex protein LAMTOR2, Ragulator2, Roadblock domain containing 3, Roadblock domain containing protein 3, Roadblock domain-containing protein 3, ROBLD 3, RP11 336K24.9.

Background: MP1 (MEK partner 1) functions as a scaffolding protein in the mitogen activated protein (MAP) kinase signaling pathway. Growth factor induced MAP kinase activation is selectively mediated by the extracellular signal-regulated kinase (ERK) cascade. MAPBPIP (mitogen-activated protein-binding protein-interacting protein), also known as p14 and late endosomal/lysosomal MP1-interacting protein, functions as an adaptor protein augmenting the regulation of the MAP kinase cascade. Partner proteins MAPBPIP and MP1 are structurally almost identical each with a five-stranded -sheet flanked between a two-helix and one-helix layer. MAPBPIP compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. Knockdown of the individual proteins in the MP1/MAPBPIP complex resulted in decreased expression of the partner proteins which implies greater stability of the heterodimeric complex than either MP1 or MAPBPIP individually. Early research suggests the MP1-MAPBPIP-MEK-1 signaling complex may be critical in the regulation of tissue homeostasis.

Pathways: PI3K-Akt Signaling