DOK7 antibody (Docking Protein 7) Primary Antibody
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- Target
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Clonality
- Polyclonal
- Conjugate
- This DOK7 antibody is un-conjugated
- Application
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human DOK7
- Isotype
- IgG
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- Application Notes
- WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C
- Expiry Date
- 12 months
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- Target
- Alternative Name
- Dok7 (DOK7 Antibody Abstract)
- Synonyms
- si:dkey-180b4.3, si:ch211-164d19.2, C4orf25, CMS1B, A930013K19Rik, AW049091, Dok-7, EF-12, Oit5, RGD1566416, dok-7, docking protein 7, DOK7, dok7, Dok7
- Background
The downstream of kinase family (Dok1-7) are members of a class of â€docking†proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with muscle-specific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA) â€" recessively inherited disorders characterized by muscle weakness.
Synonyms: Docking protein 7, DOK 7, DOK7, DOK7_HUMAN, Downstream of tyrosine kinase 7, Protein Dok-7.
- Pathways
- Skeletal Muscle Fiber Development