IGFBP2 antibody (AA 180-328)

Catalog No. ABIN1724698

Product Details anti-IGFBP2 Antibody

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Binding Specificity: AA 180-328

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGFBP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Purpose: IGFBP2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of protein IGFBP2 (aa180-328) expressed in E. Coli.

Clone: 1F6F6

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IGFBP2 antibody (ABIN1724698)

Miyake, Hara, Yamanaka, Muramaki, Gleave, Eto: "Introduction of insulin-like growth factor binding protein-2 gene into human bladder cancer cells enhances their metastatic potential." in: Oncology reports, Vol. 13, Issue 2, pp. 341-5, (2005) (PubMed).

Fisher, Meyer, Garber, Dealy: "Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth." in: Bone, Vol. 37, Issue 6, pp. 741-50, (2005) (PubMed).

Target Details for IGFBP2

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Alternative Name: IGFBP2 (IGFBP2 Products)

Background:

Description: IGFBP2: insulin-like growth factor binding protein 2. IGFBP2 is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.

Aliases: IBP2, IGF-BP53

Gene ID: 3485

HGNC: 3485

UniProt: P18065

Pathways: Myometrial Relaxation and Contraction, Growth Factor Binding, Activated T Cell Proliferation