IGFBP2 antibody (AA 35-304)

Catalog No. ABIN6654166

Product Details anti-IGFBP2 Antibody

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Binding Specificity: AA 35-304

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGFBP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: Rat IGFBP2 recombinant protein (amino acids E35-Q304) was used as the immunogen for the IGFBP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the IGFBP2 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant rat protein)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the IGFBP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for IGFBP2

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Alternative Name: IGFBP2 (IGFBP2 Products)

Synonyms: IBP2 antibody, IGF-BP53 antibody, AI255832 antibody, IBP-2 antibody, Igfbp-2 antibody, mIGFBP-2 antibody, IGFBP-2 antibody, ILGFBPA antibody, pIGFBP-2 antibody, igfbp2 antibody, MGC65741 antibody, MGC76823 antibody, MGC174445 antibody, IGFBP2 antibody, ibp2 antibody, igf-bp53 antibody, igfbp2a antibody, si:ch211-2k18.3 antibody, insulin like growth factor binding protein 2 antibody, insulin-like growth factor binding protein 2 antibody, insulin-like growth factor binding protein 2a antibody, insulin-like growth factor binding protein 2b antibody, IGFBP2 antibody, Igfbp2 antibody, igfbp2a antibody, igfbp2 antibody, igfbp2b antibody

Background: The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. Human IGFBP-2 cDNA encodes a 328 amino acid (aa) residue precursor protein with a putative 39 aa residue signal peptide that is processed to generate the 289 aa residue mature protein. IGFBP-2 contains an integrin receptor recognition sequence (RGD sequence) but lacks potential N-linked glycosylation sites. During development, IGFBP-2 is expressed in a number of tissues. The highest expression level is found in the central nervous system. In adults, high expression levels are also detected in the central nervous system and in a number of reproductive tissues. IGFBP-2 binds preferentially to IGF II, exhibiting a 2-10 fold higher affinity for IGF II than for IGF I.

UniProt: P12843

Pathways: Myometrial Relaxation and Contraction, Growth Factor Binding, Activated T Cell Proliferation