ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibody

Details for Product No. ABIN1724923
Antigen
Epitope
AA 632-693
39
13
9
8
7
7
4
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
190
34
24
9
7
7
6
2
1
1
1
1
1
1
1
1
1
Host
Mouse
105
94
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
6
4
3
3
3
2
2
2
2
2
1
1
1
Application
ELISA, Western Blotting (WB)
113
70
64
41
33
24
19
11
6
4
4
3
2
2
Options
Immunogen Purified recombinant fragment of human ABCB1 (AA 632-693) expressed in E. Coli.
Clone 6G11C12
Isotype IgG1
Purification Purified
Antigen
Alternative Name ABCB1 (ABCB1 Antibody Abstract)
Background The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. ,
Molecular Weight 141.5 kDa
Gene ID 5243
HGNC 5243
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibody (ABIN1724923) anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibody (Image 1)
Image no. 2 for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibody (ABIN1724923) anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibody (Image 2)
Image no. 3 for anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibody (ABIN1724923) anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 632-693) antibody (Image 3)
Product cited in: Rubi?, Ho?ysz, Barczak, Gryczka, ?aci?ski, Jagielski, Czernikiewicz, Pó?rolniczak, Wojewoda, Perz, Bia?ek, Morze, Kandu?a, Lisiak, Mrozikiewicz, Grodecka-Gazdecka, Rybczy?ska: "Study of ABCB1 polymorphism frequency in breast cancer patients from Poland." in: Pharmacological reports : PR, Vol. 64, Issue 6, pp. 1560-6, 2013 (PubMed).

Zhang, Wang, Cai, Jiang, Zhou, Yang, Chen, Chen, Dou: "Downregulation of gene MDR1 by shRNA to reverse multidrug-resistance of ovarian cancer A2780 cells." in: Journal of cancer research and therapeutics, Vol. 8, Issue 2, pp. 226-31, 2012 (PubMed).