PRKAG1 antibody (Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit) (AA 230-331)

Details for Product anti-PRKAG1 Antibody No. ABIN1724935
Antigen
Epitope
AA 230-331
15
8
8
8
6
4
2
2
2
2
1
1
1
1
1
Reactivity
Human
91
53
33
Host
Mouse
85
6
Clonality (Clone)
Monoclonal ()
Conjugate
This PRKAG1 antibody is un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
79
58
29
8
5
3
3
3
2
1
1
Options
Immunogen Purified recombinant fragment of human PRKAG1 (AA 230-331) expressed in E. Coli.
Clone 4A1G9
Isotype IgG1
Purification Purified
Antigen
Alternative Name PRKAG1 (PRKAG1 Antibody Abstract)
Background The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. ,
Molecular Weight 37.6 kDa
Gene ID 5571
HGNC 5571
Pathways AMPK Signaling, Regulation of Carbohydrate Metabolic Process
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1) (AA 230-331) antibody (ABIN1724935) Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using PRKAG...
Image no. 2 for anti-Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1) (AA 230-331) antibody (ABIN1724935) Immunohistochemical analysis of paraffin-embedded breast cancer tissues using PRKAG1 ...
Product cited in: Zaha, Young: "AMP-activated protein kinase regulation and biological actions in the heart." in: Circulation research, Vol. 111, Issue 6, pp. 800-14, 2012 (PubMed).

Oliveira, Zhang, Solis, Isackson, Bellahcene, Yavari, Pinter, Davies, Ge, Ashrafian, Walker, Carling, Watkins, Casadei, Redwood: "AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes." in: Circulation research, Vol. 110, Issue 9, pp. 1192-201, 2012 (PubMed).