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C-JUN antibody (Jun Proto-Oncogene) (pSer243) Primary Antibody

JUN Reactivity: Human, Mouse IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN196654
$441.10
Plus shipping costs $45.00
0.1 mL ABIN196654
0.1 mL ABIN196654
local_shipping Shipping to: United States
Available
  • Target
    C-JUN (JUN)
    Binding Specificity
    • 47
    • 44
    • 38
    • 33
    • 28
    • 19
    • 16
    • 16
    • 16
    • 16
    • 13
    • 13
    • 11
    • 11
    • 11
    • 10
    • 9
    • 9
    • 8
    • 8
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer243
    Reactivity
    • 445
    • 229
    • 212
    • 48
    • 46
    • 38
    • 26
    • 22
    • 21
    • 13
    • 13
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 434
    • 19
    • 2
    • 1
    Rabbit
    Clonality
    • 412
    • 41
    Polyclonal
    Conjugate
    • 206
    • 28
    • 21
    • 18
    • 17
    • 16
    • 16
    • 16
    • 16
    • 16
    • 15
    • 9
    • 9
    • 9
    • 9
    • 9
    • 7
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    This C-JUN antibody is un-conjugated
    Application
    • 272
    • 165
    • 144
    • 141
    • 69
    • 66
    • 51
    • 46
    • 36
    • 28
    • 13
    • 9
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Specificity
    C-Jun (phospho-Ser243) antibody detects endogenous levels of c-Jun only when phosphorylated at serine 243.
    Purification
    Immunoaffinity chromatography
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from human c-Jun around the phosphorylation site of serine 243 (P-L-SP-P-I).
  • Application Notes
    Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    C-JUN (JUN)
    Alternative Name
    AP-1 / C-Jun (JUN Antibody Abstract)
    Synonyms
    AP-1, AP1, c-Jun, fj36h07, wu:fj36h07, zgc:65863, Junc, c-jun, CG2275, D-Jun, D-jun, D-jun/Jra, DJUN, DJun, Djun, Dmel\\CG2275, JRA, JUN, Jun, V, cJun, d-JRA, d-Jun, d-jun, dAP-1, dJRA, dJUN, dJra, dJun, djun, dm-Jun, jra, jun, l(2)46Ef, l(2)IA109, l(2R)IA109, Jun proto-oncogene, AP-1 transcription factor subunit, jun proto-oncogene S homeolog, jun proto-oncogene, Jun-related antigen, jun proto-oncogene L homeolog, JUN, Jun, jun.S, jun, Jra, jun.L
    Background
    The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.Synonyms: Activator protein 1, Proto-oncogene c-jun, Transcription factor AP1, V-jun avian sarcoma virus 17 oncogene homolog, p39
    Gene ID
    3725
    NCBI Accession
    NP_002219
    UniProt
    P05412
    Pathways
    MAPK Signaling, RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins
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