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MAPT antibody (Microtubule-Associated Protein tau) (pSer404) Primary Antibody

MAPT Reactivity: Human, Mouse, Rat IF, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN196810
$441.10
Plus shipping costs $45.00
0.1 mL ABIN196810
0.1 mL ABIN196810
local_shipping Shipping to: United States
Available
  • Target
    MAPT
    Binding Specificity
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer404
    Reactivity
    • 225
    • 132
    • 128
    • 22
    • 10
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 209
    • 24
    • 6
    Rabbit
    Clonality
    • 215
    • 24
    Polyclonal
    Conjugate
    • 190
    • 19
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This MAPT antibody is un-conjugated
    Application
    • 215
    • 105
    • 55
    • 33
    • 27
    • 23
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Synthetic peptide around phosphorylation site of Serine 404 (D-T-Sp-P-R) derived from Human Tau.
  • Application Notes
    Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide, 50 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    MAPT
    Alternative Name
    MAPT / tau (MAPT Antibody Abstract)
    Synonyms
    DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, RNPTAU, pTau, tau, xtp, MAPT, PHF-tau, slc6a6, taut, wu:fc26e12, microtubule associated protein tau, microtubule-associated protein tau, microtubule associated protein tau S homeolog, Microtubule-associated protein tau, solute carrier family 6 (neurotransmitter transporter), member 6b, MAPT, Mapt, mapt.S, LOC5580230, CpipJ_CPIJ013260, tau, slc6a6b
    Background
    Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
    Molecular Weight
    48, 62, 78 KDa
    Gene ID
    9606
    UniProt
    P10636
    Pathways
    MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size
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