CD8 alpha antibody

Catalog No. ABIN933904

This Rat Monoclonal antibody specifically detects CD8 alpha in FACS, IHC and IP. It exhibits reactivity toward Mouse.

Quick Overview for CD8 alpha antibody (ABIN933904)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 53-6-7

Product Details anti-CD8 alpha Antibody

Immunogen: CD8 a antibody was raised in rat using murine thymus or spleen as the immunogen.

Isotype: IgG2a

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in 100 mM BBS, pH 8.2.

Storage: 4 °C

Storage Comment: Store at 4 °C.

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8a

Background: CD8a (Cluster of Differentiation 8a), is a human gene. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified. Synonyms: Monoclonal CD8a antibody, Anti-CD8a antibody, Ly2 antibody.

Pathways: TCR Signaling