Podoplanin antibody (PDPN)

Details for Product anti-PDPN Antibody No. ABIN2476175
Antigen
  • PDPN
  • AGGRUS
  • GP36
  • GP40
  • Gp38
  • HT1A-1
  • OTS8
  • PA2.26
  • T1A
  • T1A-2
  • OTS-8
  • RANDAM-2
  • T1-alpha
  • T1a
  • T1alpha
  • E11
  • RTI40
  • podoplanin
  • PDPN
  • Pdpn
Reactivity
Human
198
46
20
5
2
Host
Mouse
123
86
12
11
7
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Podoplanin antibody is un-conjugated
15
10
7
5
5
5
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
187
106
68
59
48
42
38
26
9
6
3
2
2
1
1
1
1
Options
Immunogen ORF Human podoplanin ectodomain expressed in E.coli
Clone 4D5aE5E6
Isotype IgG1
Specificity This antibody recognizes Human Podoplanin (gp36), a 36 kDa type I cell membrane-associated glycoprotein, with a broad spectrum of distribution, being strongly expressed on the lymphatic endothelium found in lung, placenta and skeletal muscle and to a lesser extent in brain, kidney and liver. Podoplanin is absent on blood endothelium and therefore This antibody is readily able to distinguish between lymphatic vessels and blood vasculature. Although the specific function of this protein is undetermined, Podoplanin is reported to be a reliable indicator of tumour lymphangiogenesis.
Characteristics Purified IgG
Purification Purified
Plasmids, Primers & others Plasmids, Primers & others Podoplanin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PODOPLANIN (PDPN Antibody Abstract)
Background Synonyms: AGGRUS
Gene ID 10630
UniProt Q86YL7
Pathways Dicarboxylic Acid Transport
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Product cited in: Furtado, Marinkovic, Martin, Garin, Hoch, Hubner, Chen, Genden, Skobe, Lira: "Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 12, pp. 5026-31, 2007 (PubMed).

Dadras, Paul, Bertoncini, Brown, Muzikansky, Jackson, Ellwanger, Garbe, Mihm, Detmar: "Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival." in: The American journal of pathology, Vol. 162, Issue 6, pp. 1951-60, 2003 (PubMed).

Matsui, Nagy-Bojarsky, Laakkonen, Krieger, Mechtler, Uchida, Geleff, Kang, Johnson, Kerjaschki, Kang: "Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels." in: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 8, pp. 1981-9, 2003 (PubMed).

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